733053-60-6

Upstream product

• 703-61-7 2,4-dichloroquinoline 
• 105-13-5 4-Methoxybenzyl alcohol 
• 62-53-3 aniline 

Downstream Products

• 733053-61-7 {3-[4-(4-methoxy-benzyloxy)-quinolin-2-ylsulfanyl]-propyl}-carbamic acid tert-butyl ester 
• 913253-68-6 2-amino-4-[4-(4-methoxybenzyloxy)quinolin-2-yl-amino]-butan-1-ol 
• 913253-69-7 4-amino-2-[4-(4-methoxybenzyloxy)quinolin-2-yl-amino]-butan-1-ol 
• 1122410-62-1 N₁-[4-(4-methoxybenzyloxy)-quinolin-2-yl]-N₂,N₂-dimethylpropane-1,2,3-triamine 
• 1122410-55-2 2-aminomethyl-3-[4-(4-methoxybenzyloxy)-quinolin-2-ylamino]-propan-1-ol 
• 1122410-56-3 N₁-[4-(4-methoxybenzyloxy)-quinolin-2-yl]-2-methoxymethylpropane-1,3-diamine 
• 1122410-63-2 {1-aminomethyl-2-[4-(4-methoxybenzyloxy)-quinolin-2-ylamino]ethyl}carbamic acid tert-butyl ester 
• 1427697-21-9 2-(3-((1,3-diphenyl-1H-pyrazol-4-yl)methylamino)-2-hydroxypropylamino)quinolin-4(1H)-one 
• 1427697-20-8 2-(3-((1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)methylamino)propylamino) quinolin-4(1H)-one 
• 1427697-19-5 2-(3-((3-(4-bromophenyl)-1-phenyl-1H-pyrazol-4-yl)methylamino) propylamino)quinolin-4(1H)-one 
• 1427697-18-4 2-(3-((3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylamino)propylamino)quinolin-4(1H)-one 
• 1427697-16-2 2-(3-((1-phenyl-3-p-tolyl-1H-pyrazol-4-yl)methylamino)propylamino)quinolin-4(1H)-one 
• 1427697-14-0 tert-Butyl 3-(1-(3,4-dichlorobenzylamino)-3-(4-oxo-1,4-dihydroquinolin-2-ylamino)propan-2-yloxy)-2-hydroxypropylcarbamate 
• 1427697-15-1 2-(3-((1,3-diphenyl-1H-pyrazol-4-yl)methylamino)propylamino)quinolin-4(1H)-one 

Relevant academic research and scientific papers

Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors

Five new structural analogues of substituted-1H-quinolinones (19, 20, 23, 24, and 26) have been synthesized and evaluated for Staphylococcus aureus methionyl-tRNA synthetase enzyme inhibitory activity. These compounds were also tested against pathogens of six S. aureus, two Enterococcus faecalis, and one Enterococcus faecium. Among all the synthesized quinolinones, compound 20 displayed significant inhibitory activities in the strains of E. faecalis and E. faecium.

Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent Gram-positive antibacterial activity

Optimisation of the left-hand-side aryl moiety of a file compound screening hit against Staphylococcus aureus methionyl tRNA synthetase led to the identification of a series of potent nanomolar inhibitors. The best compounds showed excellent antibacterial activity against staphylococcal and enterococcal pathogens, including strains resistant to clinical antibiotics.

Quinolones used as MRS inhibitors and bactericides

Compounds of formula (I) are inhibitors of the bacterial enzymeS aureusmethionyl tRNA synthetase and are of use in treating bacterial infections.