N-[2-(1-benzyl-piperidin-4-yl)-1-hydroxyimino-ethyl]-3-(3,4-dimethoxy-phenyl)acrylamide

Base Information

Chemical Name:N-[2-(1-benzyl-piperidin-4-yl)-1-hydroxyimino-ethyl]-3-(3,4-dimethoxy-phenyl)acrylamide
CAS No.:1332498-43-7
Molecular Formula:C₂₅H₃₁N₃O₄
Molecular Weight:437.539
Hs Code.:

Synonyms:N-[2-(1-benzyl-piperidin-4-yl)-1-hydroxyimino-ethyl]-3-(3,4-dimethoxy-phenyl)acrylamide

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Chemical Property of N-[2-(1-benzyl-piperidin-4-yl)-1-hydroxyimino-ethyl]-3-(3,4-dimethoxy-phenyl)acrylamide

Chemical Property:

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Technology Process of N-[2-(1-benzyl-piperidin-4-yl)-1-hydroxyimino-ethyl]-3-(3,4-dimethoxy-phenyl)acrylamide

There total 8 articles about N-[2-(1-benzyl-piperidin-4-yl)-1-hydroxyimino-ethyl]-3-(3,4-dimethoxy-phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332498-42-6
2-(1-benzyl-piperidin-4-yl)-N-hydroxy-acetamidine

: 39856-08-1
3,4-dimethoxy-cinnamoyl chloride

: 1332498-43-7
N-[2-(1-benzyl-piperidin-4-yl)-1-hydroxyimino-ethyl]-3-(3,4-dimethoxy-phenyl)acrylamide

Guidance literature:: With pyridine; at 25 ℃; for 12h;

Reference yield:

: 100-39-0
benzyl bromide

: 1332498-43-7
N-[2-(1-benzyl-piperidin-4-yl)-1-hydroxyimino-ethyl]-3-(3,4-dimethoxy-phenyl)acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 14 h / 65 °C

2.1: potassium carbonate / tetrahydrofuran / 0.58 h / 20 °C / Reflux

2.2: 16 h / 70 °C

3.1: magnesium / methanol / 4 h / 5 - 10 °C

4.1: hydroxylamine hydrochloride; sodium / methanol / 13 h / 75 °C

5.1: pyridine / 12 h / 25 °C

With pyridine; hydroxylamine hydrochloride; sodium; potassium carbonate; magnesium; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1332498-43-7
N-[2-(1-benzyl-piperidin-4-yl)-1-hydroxyimino-ethyl]-3-(3,4-dimethoxy-phenyl)acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrahydrofuran / 0.58 h / 20 °C / Reflux

1.2: 16 h / 70 °C

2.1: magnesium / methanol / 4 h / 5 - 10 °C

3.1: hydroxylamine hydrochloride; sodium / methanol / 13 h / 75 °C

4.1: pyridine / 12 h / 25 °C

With pyridine; hydroxylamine hydrochloride; sodium; potassium carbonate; magnesium; In tetrahydrofuran; methanol;