Technology Process of 1-(4-iodophenyl)piperidine-2,3-dione
There total 5 articles about 1-(4-iodophenyl)piperidine-2,3-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium fluoride; sodium ethanolate;
In
tetrahydrofuran; ethanol;
at 0 - 25 ℃;
Reagent/catalyst;
Temperature;
Inert atmosphere;
- Guidance literature:
-
morpholine;
With
Cyclopentanone oxime; phosphorus pentachloride; trichlorophosphate;
In
chloroform;
at -14 - 135 ℃;
for 6.5h;
4-Fluoronitrobenzene;
With
copper(l) iodide; potassium tert-butylate;
In
N,N-dimethyl-formamide;
at 0 - 30 ℃;
Temperature;
Further stages;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: thionyl chloride; bromine / 70 - 78 °C / Inert atmosphere
2: potassium fluoride; triethylamine / toluene / 3 - 10 °C / Inert atmosphere
3: potassium fluoride / acetonitrile / 25 - 30 °C / Inert atmosphere
4: sodium azide; potassium fluoride / N,N-dimethyl acetamide / 22 - 27 °C / Inert atmosphere
5: sodium ethanolate; potassium fluoride / tetrahydrofuran; ethanol / 0 - 25 °C / Inert atmosphere
With
potassium fluoride; thionyl chloride; sodium azide; bromine; sodium ethanolate; triethylamine;
In
tetrahydrofuran; ethanol; N,N-dimethyl acetamide; toluene; acetonitrile;
