1-(4-iodophenyl)-3-trimethylsilyloxy-5,6-dihydro-1H-pyridin-2-one

Base Information

• Chemical Name: 1-(4-iodophenyl)-3-trimethylsilyloxy-5,6-dihydro-1H-pyridin-2-one
• CAS No.: 1415831-80-9
• Molecular Formula: C₁₄H₁₈INO₂Si
• Molecular Weight: 387.292
• Mol file: 1415831-80-9.mol

Synonyms:1-(4-iodophenyl)-3-trimethylsilyloxy-5,6-dihydro-1H-pyridin-2-one

Chemical Property of 1-(4-iodophenyl)-3-trimethylsilyloxy-5,6-dihydro-1H-pyridin-2-one

Chemical Property:

• Boiling Point: 382.1±42.0 °C(Predicted)
• Density: 1.48±0.1 g/cm3(Predicted)

Purity/Quality:

98% HPLC ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-iodophenyl)-3-trimethylsilyloxy-5,6-dihydro-1H-pyridin-2-one

There total 1 articles about 1-(4-iodophenyl)-3-trimethylsilyloxy-5,6-dihydro-1H-pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

chloro-trimethyl-silane (75-77-4) + 1-(4-iodophenyl)piperidine-2,3-dione (1415831-82-1) → 1-(4-iodophenyl)-3-trimethylsilyloxy-5,6-dihydro-1H-pyridin-2-one (1415831-80-9)

Guidance literature:

With triethylamine; In toluene; at 0 - 50 ℃; Inert atmosphere;

Reference yield: 63.0%

1-(4-iodophenyl)-3-trimethylsilyloxy-5,6-dihydro-1H-pyridin-2-one (1415831-80-9) + ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate (27143-07-3) → 1-(4-methoxy-phenyl)-6-(4-iodo-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester (473927-64-9)

Guidance literature:

1-(4-iodophenyl)-3-trimethylsilyloxy-5,6-dihydro-1H-pyridin-2-one; ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate; With triethylamine; In ethyl acetate; at 0 ℃; Inert atmosphere; Reflux;

With hydrogenchloride; In water; ethyl acetate; at 0 - 20 ℃;

Reference yield:

1-(4-iodophenyl)-3-trimethylsilyloxy-5,6-dihydro-1H-pyridin-2-one (1415831-80-9) → 1-(4-methoxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester (503614-91-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / ethyl acetate / 0 °C / Inert atmosphere; Reflux

1.2: 0 - 20 °C

2.1: potassium phosphate; N,N`-dimethylethylenediamine / copper(l) iodide / toluene / 48 h / Inert atmosphere; Reflux

With potassium phosphate; triethylamine; N,N`-dimethylethylenediamine; copper(l) iodide; In ethyl acetate; toluene;

upstream raw materials:

chloro-trimethyl-silane

1-(4-iodophenyl)piperidine-2,3-dione

Downstream raw materials:

1-(4-methoxy-phenyl)-6-(4-iodo-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester

1-(4-methoxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester