2-[4-(ethylsulfonyl)phenyl]-N-(5-{[4-(2-hydroxyethyl)phenyl]carbonyl}-4-phenyl-1,3-thiazol-2-yl)acetamide

Base Information

Chemical Name:2-[4-(ethylsulfonyl)phenyl]-N-(5-{[4-(2-hydroxyethyl)phenyl]carbonyl}-4-phenyl-1,3-thiazol-2-yl)acetamide
CAS No.:1361413-41-3
Molecular Formula:C₂₈H₂₆N₂O₅S₂
Molecular Weight:534.657
Hs Code.:

Synonyms:2-[4-(ethylsulfonyl)phenyl]-N-(5-{[4-(2-hydroxyethyl)phenyl]carbonyl}-4-phenyl-1,3-thiazol-2-yl)acetamide

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Chemical Property of 2-[4-(ethylsulfonyl)phenyl]-N-(5-{[4-(2-hydroxyethyl)phenyl]carbonyl}-4-phenyl-1,3-thiazol-2-yl)acetamide

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Technology Process of 2-[4-(ethylsulfonyl)phenyl]-N-(5-{[4-(2-hydroxyethyl)phenyl]carbonyl}-4-phenyl-1,3-thiazol-2-yl)acetamide

There total 9 articles about 2-[4-(ethylsulfonyl)phenyl]-N-(5-{[4-(2-hydroxyethyl)phenyl]carbonyl}-4-phenyl-1,3-thiazol-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361414-36-9
2-(4-{[2-({[4-(ethylsulfonyl)phenyl]acetyl} amino)-4-phenyl-1,3-thiazol-5-yl]carbonyl}phenyl)ethyl acetate

: 1361413-41-3
2-[4-(ethylsulfonyl)phenyl]-N-(5-{[4-(2-hydroxyethyl)phenyl]carbonyl}-4-phenyl-1,3-thiazol-2-yl)acetamide

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 4h;

Reference yield:

: 1197-55-3
4-aminophenylacetic acid

: 1361413-41-3
2-[4-(ethylsulfonyl)phenyl]-N-(5-{[4-(2-hydroxyethyl)phenyl]carbonyl}-4-phenyl-1,3-thiazol-2-yl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.75 h / 0 °C

1.2: 20 - 45 °C

2.1: potassium hydroxide / ethanol; water / 20 h / Reflux

2.2: Cooling with ice

3.1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

5.1: sodium hydroxide; water / ethanol / 20 °C

5.2: pH 1

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

7.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 4 h / 20 °C

With hydrogenchloride; lithium hydroxide monohydrate; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; sodium hydroxide; sodium nitrite; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: ethyl 2-(4-(ethylthio)phenyl)acetate

: 1361413-41-3
2-[4-(ethylsulfonyl)phenyl]-N-(5-{[4-(2-hydroxyethyl)phenyl]carbonyl}-4-phenyl-1,3-thiazol-2-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

2.1: sodium hydroxide; water / ethanol / 20 °C

2.2: pH 1

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 4 h / 20 °C

With lithium hydroxide monohydrate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;