Chemical Property of 4-Mercaptophenylacetic acid
Chemical Property:
- Appearance/Colour:White Powder
- Vapor Pressure:4.54E-05mmHg at 25°C
- Melting Point:105-109 °C(lit.)
- Refractive Index:1.62
- Boiling Point:336 °C at 760 mmHg
- PKA:4.21±0.10(Predicted)
- Flash Point:157 °C
- PSA：76.10000
- Density:1.299 g/cm3
- LogP:1.60240
- Storage Temp.:-20°C Freezer, Under Inert Atmosphere
- Sensitive.:Air Sensitive
- Water Solubility.:Slightly soluble in water. Soluble in Dichloromethane, Ethanol and Methanol
- XLogP3:1.8
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:2
- Exact Mass:168.02450067
- Heavy Atom Count:11
- Complexity:139
- Purity/Quality:
-
99%, *data from raw suppliers
4-Mercaptophenylacetic acid
97% *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
37/38-41
- Safety Statements:
26-36/37/39
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC(=CC=C1CC(=O)O)S
-
Uses
4-Mercaptophenylacetic acid has been used in the preparation of small ubiquitin-like modifier peptides from bis(2-sulfanylethyl)amido peptide via sequential native chemical ligation.It can be used: On-resin preparation of peptide-α thiophenylesters which are used in a chemical ligation process for the chemical synthesis of peptides.In one pot deprotection of (acetamido-methyl)cysteine following native chemical ligation and/or desulfurization method for the preparation of peptides.Palladium facilitated deprotection of N-terminal cysteine through native chemical ligation method for the preparation of synthetically challenging proteins. 4-MERCAPTOPHENYLACETIC ACID is a redox buffer that increases the folding rate of disulfide-containing proteins realative to traditional buffers such as glutathione and glutathione-disulfide. A useful synthetic intermediate for the preparation of novel antiinflammatory agents.
