3-(2,4-dinitrophenyl)-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

Base Information

Chemical Name:3-(2,4-dinitrophenyl)-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione
CAS No.:1035556-51-4
Molecular Formula:C₂₀H₁₂FIN₆O₆
Molecular Weight:578.255
Hs Code.:

Synonyms:3-(2,4-dinitrophenyl)-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

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Chemical Property of 3-(2,4-dinitrophenyl)-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

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Technology Process of 3-(2,4-dinitrophenyl)-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

There total 8 articles about 3-(2,4-dinitrophenyl)-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1035556-27-4
5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

: 97-00-7
1-chloro-2,4-dinitro-benzene

: 1035556-51-4
3-(2,4-dinitrophenyl)-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

Guidance literature:: 5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione; With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

1-chloro-2,4-dinitro-benzene; In N,N-dimethyl-formamide; at 80 - 100 ℃; for 1h; Microwave irradiation;

Reference yield:

: 1122-67-4
6-(methylamino)pyrimidin-4(3H)-one

: 1035556-51-4
3-(2,4-dinitrophenyl)-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

Guidance literature:: Multi-step reaction with 8 steps

1: potassium carbonate / ethanol

2: 1-methyl-pyrrolidin-2-one; diphenylether / 240 °C

3: trichlorophosphate

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / 1,4-dioxane

5: acetic acid; zinc

6: hydrogenchloride; potassium iodide; sodium nitrite

7: ammonium formate; palladium(II) hydroxide / 1,4-dioxane

8: potassium carbonate / N,N-dimethyl-formamide

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ammonium formate; palladium(II) hydroxide; potassium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium iodide; sodium t-butanolate; zinc; sodium nitrite; trichlorophosphate; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; diphenylether; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.01.071

Reference yield:

: 1035556-25-2
3-benzyl-5-(2-fluoro-4-nitrophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

: 1035556-51-4
3-(2,4-dinitrophenyl)-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid; zinc

2: hydrogenchloride; potassium iodide; sodium nitrite

3: ammonium formate; palladium(II) hydroxide / 1,4-dioxane

4: potassium carbonate / N,N-dimethyl-formamide

With hydrogenchloride; ammonium formate; palladium(II) hydroxide; potassium carbonate; acetic acid; potassium iodide; zinc; sodium nitrite; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.01.071