(S)-2-tert-butoxycarbonylamino-3-(4-chlorophenyl)-3-methyl-butyric acid

Base Information

Chemical Name:(S)-2-tert-butoxycarbonylamino-3-(4-chlorophenyl)-3-methyl-butyric acid
CAS No.:853680-38-3
Molecular Formula:C₁₆H₂₂ClNO₄
Molecular Weight:327.808
Hs Code.:

Synonyms:(S)-2-tert-butoxycarbonylamino-3-(4-chlorophenyl)-3-methyl-butyric acid

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Chemical Property of (S)-2-tert-butoxycarbonylamino-3-(4-chlorophenyl)-3-methyl-butyric acid

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Technology Process of (S)-2-tert-butoxycarbonylamino-3-(4-chlorophenyl)-3-methyl-butyric acid

There total 5 articles about (S)-2-tert-butoxycarbonylamino-3-(4-chlorophenyl)-3-methyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 853680-37-2
(S)-2-amino-3-(4-chlorophenyl)-3-methyl-butyric acid hydrochloride

: 24424-99-5
di-tert-butyl dicarbonate

: 853680-38-3
(S)-2-tert-butoxycarbonylamino-3-(4-chlorophenyl)-3-methyl-butyric acid

Guidance literature:: With sodium hydroxide; In water; for 4h;

Reference yield:

: 853680-36-1
(R)-4-methylbenzenesulfinic acid[2-(4-chlorophenyl)-2-methylpropylidene]-amide

: 853680-38-3
(S)-2-tert-butoxycarbonylamino-3-(4-chlorophenyl)-3-methyl-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: isopropyl alcohol / tetrahydrofuran; toluene / 15 h / -78 - 20 °C

2: hydrogenchloride; water / 110 °C / Heating / reflux

3: sodium hydroxide / water / 4 h

With hydrogenchloride; sodium hydroxide; water; isopropyl alcohol; In tetrahydrofuran; water; toluene;

Reference yield:

: 6258-30-6
2-(4-chlorophenyl)-2-methylpropanoic acid

: 853680-38-3
(S)-2-tert-butoxycarbonylamino-3-(4-chlorophenyl)-3-methyl-butyric acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran / 3 h / 20 °C / Heating / reflux

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 2 h / -78 °C

2.2: 3 h / 20 °C

3.1: titanium(IV) tetraethanolate / dichloromethane / 4 h / Heating / reflux

4.1: isopropyl alcohol / tetrahydrofuran; toluene / 15 h / -78 - 20 °C

5.1: hydrogenchloride; water / 110 °C / Heating / reflux

6.1: sodium hydroxide / water / 4 h

With hydrogenchloride; titanium(IV) tetraethanolate; sodium hydroxide; oxalyl dichloride; water; dimethyl sulfoxide; sodium bis(2-methoxyethoxy)aluminium dihydride; isopropyl alcohol; In tetrahydrofuran; dichloromethane; water; toluene;