diethyl N-{4-[2-(2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate

Base Information

Chemical Name:diethyl N-{4-[2-(2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate
CAS No.:381691-48-1
Molecular Formula:C₂₅H₃₃N₅O₆
Molecular Weight:499.567
Hs Code.:

Synonyms:diethyl N-{4-[2-(2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate

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Chemical Property of diethyl N-{4-[2-(2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate

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Technology Process of diethyl N-{4-[2-(2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate

There total 7 articles about diethyl N-{4-[2-(2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 381691-45-8
diethyl N-{4-[2-(2-amino-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate

: 381691-48-1
diethyl N-{4-[2-(2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate

Guidance literature:: With hydrogen; palladium on activated charcoal; In trifluoroacetic acid; at 20 ℃; for 24h; under 2585.74 Torr;
DOI:10.3987/com-01-9251

Reference yield:

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 381691-48-1
diethyl N-{4-[2-(2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-methylmorpholine; 6-chloro-2,4-dimethoxy-1,3,5-triazine / dimethylformamide / 1 h / 25 °C

1.2: 2 h / 20 °C

2.1: 83 percent / hydrogen / 5 percent Pd/C / trifluoroacetic acid / 24 h / 20 °C / 2585.74 Torr

With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; hydrogen; palladium on activated charcoal; In N,N-dimethyl-formamide; trifluoroacetic acid;
DOI:10.3987/com-01-9251

Reference yield:

: 381691-42-5
methyl 4-[2-(2-chloro-3-cyanopyrid-4-yl)ethyl]benzoate

: 381691-48-1
diethyl N-{4-[2-(2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 54 percent / dimethylsulfoxide / 80 °C

2.1: aq. NaOH / methanol / 12 h / 20 °C

2.2: glacial AcOH

3.1: aq. NaOH / 2 h / Heating

3.2: glacial AcOH

4.1: N-methylmorpholine; 6-chloro-2,4-dimethoxy-1,3,5-triazine / dimethylformamide / 1 h / 25 °C

4.2: 2 h / 20 °C

5.1: 83 percent / hydrogen / 5 percent Pd/C / trifluoroacetic acid / 24 h / 20 °C / 2585.74 Torr

With 4-methyl-morpholine; sodium hydroxide; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; hydrogen; palladium on activated charcoal; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; trifluoroacetic acid;
DOI:10.3987/com-01-9251