α-benzyl ester of N-acetylaspartic adid

Base Information

• Chemical Name: α-benzyl ester of N-acetylaspartic adid
• CAS No.: 104840-92-8
• Molecular Formula: C₁₃H₁₅NO₅
• Molecular Weight: 265.266
• Mol file: 104840-92-8.mol

Synonyms:α-benzyl ester of N-acetylaspartic adid

Chemical Property of α-benzyl ester of N-acetylaspartic adid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of α-benzyl ester of N-acetylaspartic adid

There total 5 articles about α-benzyl ester of N-acetylaspartic adid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

acetic anhydride (108-24-7) + H-Asp(OH)-OBn hydrochloride → α-benzyl ester of N-acetylaspartic adid (104840-92-8)

Guidance literature:

With sodium hydrogencarbonate; for 0.75h;

DOI:10.1039/b002701o

Reference yield: 72.0%

α-benzyl,β-tert-butyl ester of N-acetylaspartic acid (117833-17-7) → α-benzyl ester of N-acetylaspartic adid (104840-92-8)

Guidance literature:

In trifluoroacetic acid; at 20 ℃; for 0.5h;

Reference yield:

(S)-3-amino-4-(benzyloxy)-4-oxobutanoic acid (7362-93-8) + acetic anhydride (108-24-7) → α-benzyl ester of N-acetylaspartic adid (104840-92-8)

Guidance literature:

With sodium acetate; In water; at 55 ℃; for 0.05h;

DOI:10.1021/ja00122a001

upstream raw materials:

α-benzyl,β-tert-butyl ester of N-acetylaspartic acid

(S)-3-amino-4-(benzyloxy)-4-oxobutanoic acid

acetic anhydride

benzyl bromide

Downstream raw materials:

Ac-AspBzl

Spaglumic acid

(S)-2-((S)-3-Acetylamino-3-benzyloxycarbonyl-propionylamino)-6-hydroxy-heptanedioic acid dimethyl ester

Refernces

• 1、 Liotta,Gibbs,Taylor,Benkovic,Benkovic. "Antibody-catalyzed rearrangement of a peptide bond: Mechanistic and kinetic investigations". . p. 4729 - 4741. Retrieved 2007/10/02.