(S)-2-((S)-3-Acetylamino-3-benzyloxycarbonyl-propionylamino)-6-hydroxy-heptanedioic acid dimethyl ester

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Chemical Name:(S)-2-((S)-3-Acetylamino-3-benzyloxycarbonyl-propionylamino)-6-hydroxy-heptanedioic acid dimethyl ester
CAS No.:1025980-67-9
Molecular Formula:C₂₂H₃₀N₂O₉
Molecular Weight:466.488
Hs Code.:

Synonyms:(S)-2-((S)-3-Acetylamino-3-benzyloxycarbonyl-propionylamino)-6-hydroxy-heptanedioic acid dimethyl ester

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Chemical Property of (S)-2-((S)-3-Acetylamino-3-benzyloxycarbonyl-propionylamino)-6-hydroxy-heptanedioic acid dimethyl ester

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Technology Process of (S)-2-((S)-3-Acetylamino-3-benzyloxycarbonyl-propionylamino)-6-hydroxy-heptanedioic acid dimethyl ester

There total 2 articles about (S)-2-((S)-3-Acetylamino-3-benzyloxycarbonyl-propionylamino)-6-hydroxy-heptanedioic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 104840-92-8
α-benzyl ester of N-acetylaspartic adid

: H-(ε-DL-hydroxy)AP(OCH3)-OCH3 hydrochloride

: 1025980-67-9
(S)-2-((S)-3-Acetylamino-3-benzyloxycarbonyl-propionylamino)-6-hydroxy-heptanedioic acid dimethyl ester

Guidance literature:: With pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; for 2.5h;
DOI:10.1039/b002701o

Reference yield:

: H-Asp(OH)-OBn hydrochloride

: 1025980-67-9
(S)-2-((S)-3-Acetylamino-3-benzyloxycarbonyl-propionylamino)-6-hydroxy-heptanedioic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / aq. NaHCO₃ / 0.75 h

2: 87 percent / EDCI; HOBt; pyridine / dimethylformamide; CH₂Cl₂ / 2.5 h

With pyridine; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; 1: Acetylation / 2: Acylation;
DOI:10.1039/b002701o