3-benzyloxy-11α-(2-N,N-diethylaminoethyloxy)-17,17-ethylenedioxyestra-1,3,5(10)-triene

Base Information

Chemical Name:3-benzyloxy-11α-(2-N,N-diethylaminoethyloxy)-17,17-ethylenedioxyestra-1,3,5(10)-triene
CAS No.:80134-29-8
Molecular Formula:C₃₃H₄₅NO₄
Molecular Weight:519.725
Hs Code.:

Synonyms:3-benzyloxy-11α-(2-N,N-diethylaminoethyloxy)-17,17-ethylenedioxyestra-1,3,5(10)-triene

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Chemical Property of 3-benzyloxy-11α-(2-N,N-diethylaminoethyloxy)-17,17-ethylenedioxyestra-1,3,5(10)-triene

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Technology Process of 3-benzyloxy-11α-(2-N,N-diethylaminoethyloxy)-17,17-ethylenedioxyestra-1,3,5(10)-triene

There total 5 articles about 3-benzyloxy-11α-(2-N,N-diethylaminoethyloxy)-17,17-ethylenedioxyestra-1,3,5(10)-triene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1069-72-3
2-bromo-N,N-diethylethanamine hydrobromide

: 80134-28-7
3-benzyloxy-17,17-ethylenedioxyestra-1,3,5(10)-trien-11α-ol

: 80134-29-8
3-benzyloxy-11α-(2-N,N-diethylaminoethyloxy)-17,17-ethylenedioxyestra-1,3,5(10)-triene

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 45 ℃; for 43h;
DOI:10.1039/P19810002401

Reference yield:

: 1089-80-1
3-hydroxy-estra-1,3,5⁽¹⁰⁾,9⁽¹¹⁾-tetraen-17-one

: 80134-29-8
3-benzyloxy-11α-(2-N,N-diethylaminoethyloxy)-17,17-ethylenedioxyestra-1,3,5(10)-triene

Guidance literature:: Multi-step reaction with 4 steps

1: 91.8 g / potassium carbonate / dimethylformamide

2: 85 g / toluene-p-sulfonic acid monohydrate / benzene / 27 h / Heating

3: 1.) B₂H₆, 2.) NaOH, H₂O₂ / 1.) THF, ambient temperature, 2 h, 2.) water, room temperature, overnight

4: 90 percent / sodium hydride / tetrahydrofuran / 43 h / 45 °C

With sodium hydroxide; dihydrogen peroxide; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; diborane; In tetrahydrofuran; N,N-dimethyl-formamide; benzene;
DOI:10.1039/P19810002401

Reference yield:

: 100-39-0
benzyl bromide

: 80134-29-8
3-benzyloxy-11α-(2-N,N-diethylaminoethyloxy)-17,17-ethylenedioxyestra-1,3,5(10)-triene

Guidance literature:: Multi-step reaction with 4 steps

1: 91.8 g / potassium carbonate / dimethylformamide

2: 85 g / toluene-p-sulfonic acid monohydrate / benzene / 27 h / Heating

3: 1.) B₂H₆, 2.) NaOH, H₂O₂ / 1.) THF, ambient temperature, 2 h, 2.) water, room temperature, overnight

4: 90 percent / sodium hydride / tetrahydrofuran / 43 h / 45 °C

With sodium hydroxide; dihydrogen peroxide; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; diborane; In tetrahydrofuran; N,N-dimethyl-formamide; benzene;
DOI:10.1039/P19810002401