1-benzo[1,3]dioxol-5-yl-N-methyl-propan-2-amine

Base Information

• Chemical Name: 1-benzo[1,3]dioxol-5-yl-N-methyl-propan-2-amine
• CAS No.: 69610-10-2
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.246
• Mol file: 69610-10-2.mol

Synonyms:(±)-N-Methyl-1-(3,4-methylenedioxyphenyl)-2-aminopropane;3,4-Methylenedioxy-N,a-dimethyl-b-phenylethylamine;3,4-Methylenedioxy-N-methylamphetamine;DL-(3,4-Methylenedioxy)methamphetamine;Ecstasy;Methylenedioxymethamphetamine;N-Methyl-3,4-methylenedioxyamphetamine;XTC;Phenethylamine,N,a-dimethyl-3,4-methylenedioxy-(6CI);(RS)-3,4-(Methylenedioxy)methamphetamine;

Chemical Property of 1-benzo[1,3]dioxol-5-yl-N-methyl-propan-2-amine

Chemical Property:

• Vapor Pressure: 0.000272mmHg at 25°C
• Boiling Point: 283.39 °C at 760 mmHg
• Flash Point: 113.23 °C
• Density: 1.1 g/cm³

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzo[1,3]dioxol-5-yl-N-methyl-propan-2-amine

There total 12 articles about 1-benzo[1,3]dioxol-5-yl-N-methyl-propan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(R)-ethyl 1-(benzo[d][1,3]dioxol-5-yl)propan-2-ylcarbamate (1616297-03-0) → (-)-3,4-Methylenedioxymethamphetamine (42542-10-9,66142-89-0,69610-10-2,81262-70-6,54946-52-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 4h; Reflux;

DOI:10.1016/j.ejmech.2014.04.044

Reference yield:

(R)-(+)-N-formyl-1-(1,3-benzodioxol-5-yl)-2-propanamine → (-)-3,4-Methylenedioxymethamphetamine (42542-10-9,66142-89-0,69610-10-2,81262-70-6,54946-52-0)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 4h; Yield given; Heating;

DOI:10.1021/jm00160a035

Reference yield:

(-)-Tenamfetamine (4764-17-4,51497-09-7,61614-60-6,65620-66-8) → (-)-3,4-Methylenedioxymethamphetamine (42542-10-9,66142-89-0,69610-10-2,81262-70-6,54946-52-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Heating

2: LAH / diethyl ether / 4 h / Heating

With lithium aluminium tetrahydride; In diethyl ether;

DOI:10.1021/jm00160a035

upstream raw materials:

(-)-Tenamfetamine

(R)-ethyl [1-(3,4-dihydroxyphenyl)propan-2-yl]carbamate

(R)-ethyl 1-(benzo[d][1,3]dioxol-5-yl)propan-2-ylcarbamate

3,4-dibenzyloxybenzaldehyde

Downstream raw materials:

(-)-Tenamfetamine

Refernces

• 1、 Taschwer, Magdalena,Seidl, Yvonne,Mohr, Stefan,Schmid, Martin G.. "Chiral separation of cathinone and amphetamine derivatives by HPLC/UV using sulfated β-cyclodextrin as chiral mobile phase additive". . p. 411 - 418. Retrieved 2014/08/05.