methyl 5-((4-chloro-5-fluoro-2-nitrophenyl)amino)-3-(((1R)-1-(2-chlorophenyl)ethyl)oxy)-2-thiophenecarboxylate

Base Information

• Chemical Name: methyl 5-((4-chloro-5-fluoro-2-nitrophenyl)amino)-3-(((1R)-1-(2-chlorophenyl)ethyl)oxy)-2-thiophenecarboxylate
• CAS No.: 960000-95-7
• Molecular Formula: C₂₀H₁₅Cl₂FN₂O₅S
• Molecular Weight: 485.32
• Mol file: 960000-95-7.mol

Synonyms:methyl 5-((4-chloro-5-fluoro-2-nitrophenyl)amino)-3-(((1R)-1-(2-chlorophenyl)ethyl)oxy)-2-thiophenecarboxylate

Chemical Property of methyl 5-((4-chloro-5-fluoro-2-nitrophenyl)amino)-3-(((1R)-1-(2-chlorophenyl)ethyl)oxy)-2-thiophenecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 5-((4-chloro-5-fluoro-2-nitrophenyl)amino)-3-(((1R)-1-(2-chlorophenyl)ethyl)oxy)-2-thiophenecarboxylate

There total 2 articles about methyl 5-((4-chloro-5-fluoro-2-nitrophenyl)amino)-3-(((1R)-1-(2-chlorophenyl)ethyl)oxy)-2-thiophenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

methyl 5-amino-3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-2-thiophenecarboxylate (929039-97-4) + 1-bromo-4-chloro-5-fluoro-2-nitrobenzene (960000-93-5) → methyl 5-((4-chloro-5-fluoro-2-nitrophenyl)amino)-3-(((1R)-1-(2-chlorophenyl)ethyl)oxy)-2-thiophenecarboxylate (960000-95-7)

Guidance literature:

With caesium carbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 60 ℃; for 15h;

Reference yield:

2-chloro-5-bromofluorobenzene (60811-18-9) → methyl 5-((4-chloro-5-fluoro-2-nitrophenyl)amino)-3-(((1R)-1-(2-chlorophenyl)ethyl)oxy)-2-thiophenecarboxylate (960000-95-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium nitrate; trifluoroacetic anhydride / dichloromethane / 2.5 h / 0 - 20 °C

2: caesium carbonate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 15 h / 60 °C

With ammonium nitrate; caesium carbonate; trifluoroacetic anhydride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In dichloromethane; toluene;

Reference yield:

methyl 5-((4-chloro-5-fluoro-2-nitrophenyl)amino)-3-(((1R)-1-(2-chlorophenyl)ethyl)oxy)-2-thiophenecarboxylate (960000-95-7) → methyl 5-((2-amino-4-chloro-5-fluorophenyl)amino)-3-(((1R)-1-(2-chlorophenyl)ethyl)oxy)-2-thiophenecarboxylate (960001-64-3)

Guidance literature:

methyl 5-((4-chloro-5-fluoro-2-nitrophenyl)amino)-3-(((1R)-1-(2-chlorophenyl)ethyl)oxy)-2-thiophenecarboxylate; With iron; acetic acid; at 55 ℃;

With sodium hydroxide; water; sodium hydrogencarbonate; at 20 ℃;

upstream raw materials:

methyl 5-amino-3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-2-thiophenecarboxylate

1-bromo-4-chloro-5-fluoro-2-nitrobenzene

2-chloro-5-bromofluorobenzene

Downstream raw materials:

methyl 5-((2-amino-4-chloro-5-fluorophenyl)amino)-3-(((1R)-1-(2-chlorophenyl)ethyl)oxy)-2-thiophenecarboxylate

methyl 5-(5-chloro-6-fluoro-1H-benzimidazol-1-yl)-3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-2-thiophenecarboxylate

methyl 5-(5-chloro-6-fluoro-1H-benzimidazol-1-yl)-3-{[(1R)-1-(2-chloro-3-hydroxyphenyl)ethyl]oxy}-2-thiophenecarboxylate

Refernces

• 1、 -. "BENZIMIDAZOLE THIOPHENE COMPOUNDS". Page/Page column 224-225. . Retrieved 2008/06/13.