methyl 5-((2-amino-4-chloro-5-fluorophenyl)amino)-3-(((1R)-1-(2-chlorophenyl)ethyl)oxy)-2-thiophenecarboxylate

Base Information

Chemical Name:methyl 5-((2-amino-4-chloro-5-fluorophenyl)amino)-3-(((1R)-1-(2-chlorophenyl)ethyl)oxy)-2-thiophenecarboxylate
CAS No.:960001-64-3
Molecular Formula:C₂₀H₁₇Cl₂FN₂O₃S
Molecular Weight:455.337
Hs Code.:

Synonyms:methyl 5-((2-amino-4-chloro-5-fluorophenyl)amino)-3-(((1R)-1-(2-chlorophenyl)ethyl)oxy)-2-thiophenecarboxylate

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Chemical Property of methyl 5-((2-amino-4-chloro-5-fluorophenyl)amino)-3-(((1R)-1-(2-chlorophenyl)ethyl)oxy)-2-thiophenecarboxylate

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Technology Process of methyl 5-((2-amino-4-chloro-5-fluorophenyl)amino)-3-(((1R)-1-(2-chlorophenyl)ethyl)oxy)-2-thiophenecarboxylate

There total 3 articles about methyl 5-((2-amino-4-chloro-5-fluorophenyl)amino)-3-(((1R)-1-(2-chlorophenyl)ethyl)oxy)-2-thiophenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 960000-95-7
methyl 5-((4-chloro-5-fluoro-2-nitrophenyl)amino)-3-(((1R)-1-(2-chlorophenyl)ethyl)oxy)-2-thiophenecarboxylate

: 960001-64-3
methyl 5-((2-amino-4-chloro-5-fluorophenyl)amino)-3-(((1R)-1-(2-chlorophenyl)ethyl)oxy)-2-thiophenecarboxylate

Guidance literature:: methyl 5-((4-chloro-5-fluoro-2-nitrophenyl)amino)-3-(((1R)-1-(2-chlorophenyl)ethyl)oxy)-2-thiophenecarboxylate; With iron; acetic acid; at 55 ℃;

With sodium hydroxide; water; sodium hydrogencarbonate; at 20 ℃;

Reference yield:

: 960000-93-5
1-bromo-4-chloro-5-fluoro-2-nitrobenzene

: 960001-64-3
methyl 5-((2-amino-4-chloro-5-fluorophenyl)amino)-3-(((1R)-1-(2-chlorophenyl)ethyl)oxy)-2-thiophenecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 15 h / 60 °C

2: iron; acetic acid / 55 °C

With iron; caesium carbonate; acetic acid; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene;

Reference yield:

: 60811-18-9
2-chloro-5-bromofluorobenzene

: 960001-64-3
methyl 5-((2-amino-4-chloro-5-fluorophenyl)amino)-3-(((1R)-1-(2-chlorophenyl)ethyl)oxy)-2-thiophenecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium nitrate; trifluoroacetic anhydride / dichloromethane / 2.5 h / 0 - 20 °C

2: caesium carbonate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 15 h / 60 °C

3: iron; acetic acid / 55 °C

With ammonium nitrate; iron; caesium carbonate; acetic acid; trifluoroacetic anhydride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In dichloromethane; toluene;