Technology Process of (10R,13S,17R)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
There total 37 articles about (10R,13S,17R)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sulfuric acid; water;
In
tetrahydrofuran;
at 65 - 68 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 80 percent NaH, Et3N / 1,2-dimethoxy-ethane; paraffin / 1.) 3.5 h, reflux; 2.) 40 min
2: 1.) 2,4,6-trimethylphenol, pyridine; 2.) oxalic acid / 1.) methylcyclohexane, 13.5 h, 98 deg C, irradiation
3: 99 percent / LiAlH4 / diethyl ether
4: 62 percent / K, aniline, NH3 / tetrahydrofuran / 1 h
5: 76 percent / 2-butanone, aluminium isopropylate, mol. sieve / benzene
6: 0.16 g / LDA / tetrahydrofuran
With
pyridine; lithium aluminium tetrahydride; molecular sieve; Mesitol; ammonia; oxalic acid; aluminum isopropoxide; sodium hydride; triethylamine; aniline; butanone; lithium diisopropyl amide;
In
tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; paraffin; benzene;
DOI:10.1002/hlca.19850680430
- Guidance literature:
-
Multi-step reaction with 2 steps
1: NBS / acetone
2: (i) liq. NH3 (ii) /BRN= 4147360/, benzene, Et2O
With
N-Bromosuccinimide;
In
acetone;
DOI:10.1002/hlca.19710540852
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