4-[N-benzyl-N-(4-benzyloxy)but-2-enylamino]-1-diazo-2-butanone

Base Information

• Chemical Name: 4-[N-benzyl-N-(4-benzyloxy)but-2-enylamino]-1-diazo-2-butanone
• CAS No.: 790251-81-9
• Molecular Formula: C₂₂H₂₅N₃O₂
• Molecular Weight: 363.459
• Mol file: 790251-81-9.mol

Synonyms:4-[N-benzyl-N-(4-benzyloxy)but-2-enylamino]-1-diazo-2-butanone

Chemical Property of 4-[N-benzyl-N-(4-benzyloxy)but-2-enylamino]-1-diazo-2-butanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[N-benzyl-N-(4-benzyloxy)but-2-enylamino]-1-diazo-2-butanone

There total 3 articles about 4-[N-benzyl-N-(4-benzyloxy)but-2-enylamino]-1-diazo-2-butanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-bromoethyl diazomethyl ketone (59813-11-5) + (Z)-N-benzyl-4-(benzyloxy)but-2-en-1-amine (184228-84-0) → 4-[N-benzyl-N-(4-benzyloxy)but-2-enylamino]-1-diazo-2-butanone (790251-81-9)

Guidance literature:

With triethylamine; In ethyl acetate; at 20 ℃; for 5h;

DOI:10.1021/jo049540v

Reference yield:

(Z)-4-benzyloxy-but-2-en-1-ol (81028-03-7) → 4-[N-benzyl-N-(4-benzyloxy)but-2-enylamino]-1-diazo-2-butanone (790251-81-9)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 2 h / 20 °C

2: 6.7 g / Et₃N / tetrahydrofuran / 4 h / 20 °C

3: 82 percent / Et₃N / ethyl acetate / 5 h / 20 °C

With triethylamine; In tetrahydrofuran; dichloromethane; ethyl acetate;

DOI:10.1021/jo049540v

Reference yield:

(Z)-4-(phenylmethoxy)-2-butenyl methanesulfonate (99439-87-9) → 4-[N-benzyl-N-(4-benzyloxy)but-2-enylamino]-1-diazo-2-butanone (790251-81-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 6.7 g / Et₃N / tetrahydrofuran / 4 h / 20 °C

2: 82 percent / Et₃N / ethyl acetate / 5 h / 20 °C

With triethylamine; In tetrahydrofuran; ethyl acetate;

DOI:10.1021/jo049540v

upstream raw materials:

2-bromoethyl diazomethyl ketone

(Z)-N-benzyl-4-(benzyloxy)but-2-en-1-amine

(Z)-4-benzyloxy-but-2-en-1-ol

(Z)-4-(phenylmethoxy)-2-butenyl methanesulfonate