3-cyano-4-[2-pyridazin-4-yl-4-(trifluoromethyl)benzyl]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide

Base Information

Chemical Name:3-cyano-4-[2-pyridazin-4-yl-4-(trifluoromethyl)benzyl]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide
CAS No.:1354917-47-7
Molecular Formula:C₂₁H₁₃F₃N₆O₂S₂
Molecular Weight:502.5
Hs Code.:

Synonyms:3-cyano-4-[2-pyridazin-4-yl-4-(trifluoromethyl)benzyl]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide

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Chemical Property of 3-cyano-4-[2-pyridazin-4-yl-4-(trifluoromethyl)benzyl]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide

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Technology Process of 3-cyano-4-[2-pyridazin-4-yl-4-(trifluoromethyl)benzyl]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide

There total 7 articles about 3-cyano-4-[2-pyridazin-4-yl-4-(trifluoromethyl)benzyl]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354917-98-8
3-cyano-N-(2,4-dimethoxybenzyl)-4-[2-pyridazin-4-yl-4-(trifluoromethyl)benzyl]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide

: 1354917-47-7
3-cyano-4-[2-pyridazin-4-yl-4-(trifluoromethyl)benzyl]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide

Guidance literature:: 3-cyano-N-(2,4-dimethoxybenzyl)-4-[2-pyridazin-4-yl-4-(trifluoromethyl)benzyl]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2h;

With methanol;

Reference yield:

: 1261583-46-3
4-bromo-3-cyanobenzene-1-sulfonyl chloride

: 1354917-47-7
3-cyano-4-[2-pyridazin-4-yl-4-(trifluoromethyl)benzyl]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium bis(trimethylsilyl)azanide / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

1.2: 3 h / 20 °C

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 6 h / Reflux

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 6 h / 65 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

With lithium bis(trimethylsilyl)azanide; potassium acetate; potassium carbonate; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; dichloromethane; 3.1: Suzuki Coupling;

Reference yield:

: 1354917-94-4
ethyl 2-pyridazin-4-yl-4-(trifluoromethyl)benzoate

: 1354917-47-7
3-cyano-4-[2-pyridazin-4-yl-4-(trifluoromethyl)benzyl]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C

2: phosphorus tribromide / dichloromethane / 0.5 h / 0 °C

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 6 h / 65 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

With lithium aluminium tetrahydride; phosphorus tribromide; potassium carbonate; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; 3: Suzuki Coupling;