(2-Trifluoromethoxy-6-trimethylsilanylethynyl-phenyl)-carbamic acid ethyl ester

Base Information

Chemical Name:(2-Trifluoromethoxy-6-trimethylsilanylethynyl-phenyl)-carbamic acid ethyl ester
CAS No.:396075-92-6
Molecular Formula:C₁₅H₁₈F₃NO₃Si
Molecular Weight:345.394
Hs Code.:

Synonyms:(2-Trifluoromethoxy-6-trimethylsilanylethynyl-phenyl)-carbamic acid ethyl ester

Suppliers and Price of (2-Trifluoromethoxy-6-trimethylsilanylethynyl-phenyl)-carbamic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Alichem
Ethyl(2-(trifluoromethoxy)-6-((trimethylsilyl)ethynyl)phenyl)carbamate
1g
$ 674.24

Total 2 raw suppliers

Chemical Property of (2-Trifluoromethoxy-6-trimethylsilanylethynyl-phenyl)-carbamic acid ethyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Ethyl(2-(trifluoromethoxy)-6-((trimethylsilyl)ethynyl)phenyl)carbamate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2-Trifluoromethoxy-6-trimethylsilanylethynyl-phenyl)-carbamic acid ethyl ester

There total 3 articles about (2-Trifluoromethoxy-6-trimethylsilanylethynyl-phenyl)-carbamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 396075-93-7
(2-iodo-6-trifluoromethoxy-phenyl)-carbamic acid ethyl ester

: 1066-54-2
trimethylsilylacetylene

: 396075-92-6
(2-Trifluoromethoxy-6-trimethylsilanylethynyl-phenyl)-carbamic acid ethyl ester

Guidance literature:: (2-iodo-6-trifluoromethoxy-phenyl)-carbamic acid ethyl ester; With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; at 20 ℃; for 0.5h;

trimethylsilylacetylene; at 20 ℃; for 1.5h;

Reference yield:

: 259137-83-2
(2-Trifluoromethoxy-phenyl)-carbamic acid ethyl ester

: 396075-92-6
(2-Trifluoromethoxy-6-trimethylsilanylethynyl-phenyl)-carbamic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sec.-butyllithium / cyclohexane; tetrahydrofuran / 1 h / -78 °C

1.2: 0.67 h / -78 °C

2.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 0.5 h / 20 °C

2.2: 1.5 h / 20 °C

With sec.-butyllithium; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; cyclohexane;

Reference yield:

: 1535-75-7
2-trifluoromethoxy aniline

: 396075-92-6
(2-Trifluoromethoxy-6-trimethylsilanylethynyl-phenyl)-carbamic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / 1,2-dimethoxyethane; mineral oil / -5 - 20 °C

1.2: 3.5 h / 20 °C / Reflux

2.1: sec.-butyllithium / cyclohexane; tetrahydrofuran / 1 h / -78 °C

2.2: 0.67 h / -78 °C

3.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 0.5 h / 20 °C

3.2: 1.5 h / 20 °C

With sec.-butyllithium; sodium hydride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; 1,2-dimethoxyethane; cyclohexane; mineral oil;