N-[(3,5-dimethylphenyl)methyl]-N-methyl-1-(2-methylphenyl)-6-oxooctahydropyrrolo[1,2-a]piperazine-2-carboxamide

Base Information

Chemical Name:N-[(3,5-dimethylphenyl)methyl]-N-methyl-1-(2-methylphenyl)-6-oxooctahydropyrrolo[1,2-a]piperazine-2-carboxamide
CAS No.:1453068-13-7
Molecular Formula:C₂₅H₃₁N₃O₂
Molecular Weight:405.54
Hs Code.:

Synonyms:N-[(3,5-dimethylphenyl)methyl]-N-methyl-1-(2-methylphenyl)-6-oxooctahydropyrrolo[1,2-a]piperazine-2-carboxamide

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Chemical Property of N-[(3,5-dimethylphenyl)methyl]-N-methyl-1-(2-methylphenyl)-6-oxooctahydropyrrolo[1,2-a]piperazine-2-carboxamide

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Technology Process of N-[(3,5-dimethylphenyl)methyl]-N-methyl-1-(2-methylphenyl)-6-oxooctahydropyrrolo[1,2-a]piperazine-2-carboxamide

There total 6 articles about N-[(3,5-dimethylphenyl)methyl]-N-methyl-1-(2-methylphenyl)-6-oxooctahydropyrrolo[1,2-a]piperazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-[(3,5-dimethylphenyl)methyl]-N-methyl-1-(2-methylphenyl)-6-oxooctahydropyrrolo[1,2-a]piperazine-2-carboxamide

: 1453068-14-8
N-[(3,5-dimethylphenyl)methyl]-N-methyl-1-(2-methylphenyl)-6-oxooctahydropyrrolo[1,2-a]piperazine-2-carboxamide

: 1453068-13-7
N-[(3,5-dimethylphenyl)methyl]-N-methyl-1-(2-methylphenyl)-6-oxooctahydropyrrolo[1,2-a]piperazine-2-carboxamide

Guidance literature:: With Chiralpak AD-H; In hexane; isopropyl alcohol; Resolution of racemate;

Reference yield:

: 27129-86-8
1-bromomethyl-3,5-dimethylbenzene

: 1453068-14-8
N-[(3,5-dimethylphenyl)methyl]-N-methyl-1-(2-methylphenyl)-6-oxooctahydropyrrolo[1,2-a]piperazine-2-carboxamide

: 1453068-13-7
N-[(3,5-dimethylphenyl)methyl]-N-methyl-1-(2-methylphenyl)-6-oxooctahydropyrrolo[1,2-a]piperazine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol / 5 h / 50 °C

2.1: triethylamine / ethyl acetate / 1.5 h / 0 °C

2.2: 2 h / 20 °C

3.1: Chiralpak AD-H / hexane; isopropyl alcohol / Resolution of racemate

With triethylamine; In methanol; hexane; ethyl acetate; isopropyl alcohol;

Reference yield:

: 1228573-50-9
N-[2-(benzyloxycarbonylamino)ethyl]pent-4-ynamide

: 1453068-14-8
N-[(3,5-dimethylphenyl)methyl]-N-methyl-1-(2-methylphenyl)-6-oxooctahydropyrrolo[1,2-a]piperazine-2-carboxamide

: 1453068-13-7
N-[(3,5-dimethylphenyl)methyl]-N-methyl-1-(2-methylphenyl)-6-oxooctahydropyrrolo[1,2-a]piperazine-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 3 h / 25 °C / Inert atmosphere

2.1: bis-[(trifluoroacetoxy)iodo]benzene / 2,2,2-trifluoroethanol / 3 h / 0 °C

3.1: hydrogenchloride; 5%-palladium/activated carbon; hydrogen / methanol; water / 30 h / 3800.26 Torr

4.1: hydrogenchloride / diethyl ether / 0.58 h / 20 °C

5.1: triethylamine / ethyl acetate / 1.5 h / 0 °C

5.2: 2 h / 20 °C

6.1: Chiralpak AD-H / hexane; isopropyl alcohol / Resolution of racemate

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 5%-palladium/activated carbon; hydrogen; triethylamine; bis-[(trifluoroacetoxy)iodo]benzene; In methanol; diethyl ether; hexane; 2,2,2-trifluoroethanol; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;