1-(tert-Butoxycarbonylamino)-7-[(2-hydroxy-5-methoxyphenyl)methyl]-1H-benzotriazole

Base Information

• Chemical Name: 1-(tert-Butoxycarbonylamino)-7-[(2-hydroxy-5-methoxyphenyl)methyl]-1H-benzotriazole
• CAS No.: 215807-51-5
• Molecular Formula: C₁₉H₂₂N₄O₄
• Molecular Weight: 370.408
• Mol file: 215807-51-5.mol

Synonyms:1-(tert-Butoxycarbonylamino)-7-[(2-hydroxy-5-methoxyphenyl)methyl]-1H-benzotriazole

Chemical Property of 1-(tert-Butoxycarbonylamino)-7-[(2-hydroxy-5-methoxyphenyl)methyl]-1H-benzotriazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(tert-Butoxycarbonylamino)-7-[(2-hydroxy-5-methoxyphenyl)methyl]-1H-benzotriazole

There total 3 articles about 1-(tert-Butoxycarbonylamino)-7-[(2-hydroxy-5-methoxyphenyl)methyl]-1H-benzotriazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1-(tert-Butoxycarbonylamino)-7-[hydroxy(2-benzyloxy-5-methoxyphenyl)methyl]-1H-benzotriazole (215807-45-7) → 1-(tert-Butoxycarbonylamino)-7-[(2-hydroxy-5-methoxyphenyl)methyl]-1H-benzotriazole (215807-51-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 4h;

DOI:10.1055/s-1998-1878

Reference yield:

2-benzyloxy-5-methoxybenzaldehyde (56979-57-8) → 1-(tert-Butoxycarbonylamino)-7-[(2-hydroxy-5-methoxyphenyl)methyl]-1H-benzotriazole (215807-51-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: cerium(III) chloride; BuLi / tetrahydrofuran; hexane; various solvent(s) / 3.5 h / -70 - 0 °C

1.2: 73 percent / tetrahydrofuran; hexane; various solvent(s) / 16 h / -78 - 20 °C

2.1: 75 percent / H₂ / 5 percent Pd/C / methanol / 4 h / 20 °C

With n-butyllithium; cerium(III) chloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane;

DOI:10.1039/b103834f

Reference yield:

1-(tert-Butoxycarbonylamino)-1H-benzotriazole (181707-16-4) → 1-(tert-Butoxycarbonylamino)-7-[(2-hydroxy-5-methoxyphenyl)methyl]-1H-benzotriazole (215807-51-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: cerium(III) chloride; BuLi / tetrahydrofuran; hexane; various solvent(s) / 3.5 h / -70 - 0 °C

1.2: 73 percent / tetrahydrofuran; hexane; various solvent(s) / 16 h / -78 - 20 °C

2.1: 75 percent / H₂ / 5 percent Pd/C / methanol / 4 h / 20 °C

With n-butyllithium; cerium(III) chloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane;

DOI:10.1039/b103834f

upstream raw materials:

1-(tert-Butoxycarbonylamino)-7-[hydroxy(2-benzyloxy-5-methoxyphenyl)methyl]-1H-benzotriazole

2-benzyloxy-5-methoxybenzaldehyde

1-(tert-Butoxycarbonylamino)-1H-benzotriazole