1-(Hydroxymethyl)-4-phenyl-2-tetrazoline-5-thione

Base Information

• Chemical Name: 1-(Hydroxymethyl)-4-phenyl-2-tetrazoline-5-thione
• CAS No.: 32550-63-3
• Molecular Formula: C8H8 N4 O S
• Molecular Weight: 208.24
• Hs Code.: 2933990090
• Mol file: 32550-63-3.mol

Synonyms:2-Tetrazoline-5-thione,1-(hydroxymethyl)-4-phenyl- (7CI,8CI)

Chemical Property of 1-(Hydroxymethyl)-4-phenyl-2-tetrazoline-5-thione

Chemical Property:

• Vapor Pressure: 0.000452mmHg at 25°C
• Boiling Point: 301.9°Cat760mmHg
• Flash Point: 136.4°C
• PSA: 87.96000
• Density: 1.47g/cm³
• LogP: 0.74810

Purity/Quality:

98%,99%, ^*data from raw suppliers

4,5-DIHYDRO-4-(HYDROXYMETHYL)-1-PHENYL-1H-TETRAZOLE-5-THIONE AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(Hydroxymethyl)-4-phenyl-2-tetrazoline-5-thione

There total 4 articles about 1-(Hydroxymethyl)-4-phenyl-2-tetrazoline-5-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-Oxo-pentanoic acid 4-phenyl-5-thioxo-4,5-dihydro-tetrazol-1-ylmethyl ester (96026-13-0) → 1,4-dihydro-1-hydroxymethyl-4-phenyltetrazol-5-thione (32550-63-3)

Guidance literature:

With sodium metabisulfite; sodium thiosulfate; In tetrahydrofuran; water; for 0.5h; Product distribution; Ambient temperature; deprotection;

DOI:10.1246/cl.1988.585

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1-phenyl-1H-tetrazole-5-thiol (86-93-1) → 1,4-dihydro-1-hydroxymethyl-4-phenyltetrazol-5-thione (32550-63-3)

Guidance literature:

With water; at 60 ℃;

DOI:10.1016/j.bmcl.2015.04.070

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1-Phenyl-1H-tetrazole-5-thiol (86-93-1) → 1,4-dihydro-1-hydroxymethyl-4-phenyltetrazol-5-thione (32550-63-3)

Guidance literature:

In water; Heating;

DOI:10.1007/BF00811024

upstream raw materials:

4-Oxo-pentanoic acid 4-phenyl-5-thioxo-4,5-dihydro-tetrazol-1-ylmethyl ester

formaldehyd

1-Phenyl-1H-tetrazole-5-thiol

1-phenyl-1H-tetrazole-5-thiol

Downstream raw materials:

4-Oxo-pentanoic acid 4-phenyl-5-thioxo-4,5-dihydro-tetrazol-1-ylmethyl ester

BI-83B₃

ethyl α-[5-(1-phenyltetrazolyl)thio]acetate

Refernces

• 1、 Foeldenyi, R.. "New 1H-Tetrazol-5-thiol Derivatives as Pesticides, II. Cyanodithioimidocarbonic acid esters". . p. 1035 - 1044. Retrieved 2007/10/03.