(2-methoxy-5-(2-((E)-3-methyl-5-((S)-3,3-dimethyloxiran-2-yl)pent-2-enyl)-1,3-dithian-2-yl)phenoxy)triisopropylsilane

Base Information

• Chemical Name: (2-methoxy-5-(2-((E)-3-methyl-5-((S)-3,3-dimethyloxiran-2-yl)pent-2-enyl)-1,3-dithian-2-yl)phenoxy)triisopropylsilane
• CAS No.: 1507365-70-9
• Molecular Formula: C₃₀H₅₀O₃S₂Si
• Molecular Weight: 550.943
• Mol file: 1507365-70-9.mol

Synonyms:(2-methoxy-5-(2-((E)-3-methyl-5-((S)-3,3-dimethyloxiran-2-yl)pent-2-enyl)-1,3-dithian-2-yl)phenoxy)triisopropylsilane

Chemical Property of (2-methoxy-5-(2-((E)-3-methyl-5-((S)-3,3-dimethyloxiran-2-yl)pent-2-enyl)-1,3-dithian-2-yl)phenoxy)triisopropylsilane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-methoxy-5-(2-((E)-3-methyl-5-((S)-3,3-dimethyloxiran-2-yl)pent-2-enyl)-1,3-dithian-2-yl)phenoxy)triisopropylsilane

There total 2 articles about (2-methoxy-5-(2-((E)-3-methyl-5-((S)-3,3-dimethyloxiran-2-yl)pent-2-enyl)-1,3-dithian-2-yl)phenoxy)triisopropylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

5-(1,3-dithian-2-yl)-2-methoxyphenoxytriisopropylsilane (1507365-69-6) + (S)-3-((E)-5-Bromo-3-methyl-pent-3-enyl)-2,2-dimethyl-oxirane (153541-25-4) → (2-methoxy-5-(2-((E)-3-methyl-5-((S)-3,3-dimethyloxiran-2-yl)pent-2-enyl)-1,3-dithian-2-yl)phenoxy)triisopropylsilane (1507365-70-9)

Guidance literature:

5-(1,3-dithian-2-yl)-2-methoxyphenoxytriisopropylsilane; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; Inert atmosphere;

(S)-3-((E)-5-Bromo-3-methyl-pent-3-enyl)-2,2-dimethyl-oxirane; In tetrahydrofuran; hexane; for 0.5h; Inert atmosphere;

DOI:10.1021/ol403289y

Reference yield:

4-methoxy-3-(triisopropylsilyloxy)-benzaldehyde (179260-96-9) → (2-methoxy-5-(2-((E)-3-methyl-5-((S)-3,3-dimethyloxiran-2-yl)pent-2-enyl)-1,3-dithian-2-yl)phenoxy)triisopropylsilane (1507365-70-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: silica gel; thionyl chloride / benzene / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0 °C / Inert atmosphere

2.2: 0.5 h / Inert atmosphere

With n-butyllithium; thionyl chloride; silica gel; In tetrahydrofuran; hexane; benzene;

DOI:10.1021/ol403289y

Reference yield: 82.0%

(2-methoxy-5-(2-((E)-3-methyl-5-((S)-3,3-dimethyloxiran-2-yl)pent-2-enyl)-1,3-dithian-2-yl)phenoxy)triisopropylsilane (1507365-70-9) → 2-methoxy-5-((E)-4-methyl-6-(3,3-dimethyloxiran-2-yl)hex-3-enyl)phenoxytriisopropylsilane (1507365-71-0)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 20 - 90 ℃; for 6h; Inert atmosphere;

DOI:10.1021/ol403289y

upstream raw materials:

4-methoxy-3-(triisopropylsilyloxy)-benzaldehyde

5-(1,3-dithian-2-yl)-2-methoxyphenoxytriisopropylsilane

(S)-3-((E)-5-Bromo-3-methyl-pent-3-enyl)-2,2-dimethyl-oxirane

Downstream raw materials:

2-methoxy-5-((E)-4-methyl-6-(3,3-dimethyloxiran-2-yl)hex-3-enyl)phenoxytriisopropylsilane