2-methoxy-5-((E)-4-methyl-6-(3,3-dimethyloxiran-2-yl)hex-3-enyl)phenoxytriisopropylsilane

Base Information

• Chemical Name: 2-methoxy-5-((E)-4-methyl-6-(3,3-dimethyloxiran-2-yl)hex-3-enyl)phenoxytriisopropylsilane
• CAS No.: 1507365-71-0
• Molecular Formula: C₂₇H₄₆O₃Si
• Molecular Weight: 446.746
• Mol file: 1507365-71-0.mol

Synonyms:2-methoxy-5-((E)-4-methyl-6-(3,3-dimethyloxiran-2-yl)hex-3-enyl)phenoxytriisopropylsilane

Chemical Property of 2-methoxy-5-((E)-4-methyl-6-(3,3-dimethyloxiran-2-yl)hex-3-enyl)phenoxytriisopropylsilane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methoxy-5-((E)-4-methyl-6-(3,3-dimethyloxiran-2-yl)hex-3-enyl)phenoxytriisopropylsilane

There total 3 articles about 2-methoxy-5-((E)-4-methyl-6-(3,3-dimethyloxiran-2-yl)hex-3-enyl)phenoxytriisopropylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(2-methoxy-5-(2-((E)-3-methyl-5-((S)-3,3-dimethyloxiran-2-yl)pent-2-enyl)-1,3-dithian-2-yl)phenoxy)triisopropylsilane (1507365-70-9) → 2-methoxy-5-((E)-4-methyl-6-(3,3-dimethyloxiran-2-yl)hex-3-enyl)phenoxytriisopropylsilane (1507365-71-0)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 20 - 90 ℃; for 6h; Inert atmosphere;

DOI:10.1021/ol403289y

Reference yield:

4-methoxy-3-(triisopropylsilyloxy)-benzaldehyde (179260-96-9) → 2-methoxy-5-((E)-4-methyl-6-(3,3-dimethyloxiran-2-yl)hex-3-enyl)phenoxytriisopropylsilane (1507365-71-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: silica gel; thionyl chloride / benzene / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0 °C / Inert atmosphere

2.2: 0.5 h / Inert atmosphere

3.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 6 h / 20 - 90 °C / Inert atmosphere

With n-butyllithium; thionyl chloride; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; silica gel; In tetrahydrofuran; hexane; toluene; benzene;

DOI:10.1021/ol403289y

Reference yield:

5-(1,3-dithian-2-yl)-2-methoxyphenoxytriisopropylsilane (1507365-69-6) → 2-methoxy-5-((E)-4-methyl-6-(3,3-dimethyloxiran-2-yl)hex-3-enyl)phenoxytriisopropylsilane (1507365-71-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0 °C / Inert atmosphere

1.2: 0.5 h / Inert atmosphere

2.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 6 h / 20 - 90 °C / Inert atmosphere

With n-butyllithium; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In tetrahydrofuran; hexane; toluene;

DOI:10.1021/ol403289y

upstream raw materials:

4-methoxy-3-(triisopropylsilyloxy)-benzaldehyde

5-(1,3-dithian-2-yl)-2-methoxyphenoxytriisopropylsilane

(2-methoxy-5-(2-((E)-3-methyl-5-((S)-3,3-dimethyloxiran-2-yl)pent-2-enyl)-1,3-dithian-2-yl)phenoxy)triisopropylsilane