Benzyloxycarbonyl-L-phenylalanyl-N^ε-tert-butyloxycarbonyl-L-lysyl-L-leucin-amid

Base Information

• Chemical Name: Benzyloxycarbonyl-L-phenylalanyl-N^ε-tert-butyloxycarbonyl-L-lysyl-L-leucin-amid
• CAS No.: 149036-80-6
• Molecular Formula: C₃₄H₄₉N₅O₇
• Molecular Weight: 639.792

Synonyms:Benzyloxycarbonyl-L-phenylalanyl-N^ε-tert-butyloxycarbonyl-L-lysyl-L-leucin-amid

Chemical Property of Benzyloxycarbonyl-L-phenylalanyl-N^ε-tert-butyloxycarbonyl-L-lysyl-L-leucin-amid

Chemical Property:

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Technology Process of Benzyloxycarbonyl-L-phenylalanyl-N^ε-tert-butyloxycarbonyl-L-lysyl-L-leucin-amid

There total 4 articles about Benzyloxycarbonyl-L-phenylalanyl-N^ε-tert-butyloxycarbonyl-L-lysyl-L-leucin-amid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Cbz-L-Phe (1161-13-3) → Benzyloxycarbonyl-L-phenylalanyl-Nε-tert-butyloxycarbonyl-L-lysyl-L-leucin-amid (149036-80-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1a) HOBt, DCC, 2) N-ethylmorpholine / 1a) DMF, 0 deg C, 1 h, 1b) r.t., 1 h, 2) DMF, r.t., pH 7, 3 d

2: 98 percent / 1N NaOH / dioxane; H₂O / Ambient temperature

3: 1a) HOBt, DCC, 2) N-ethylmorpholine / 1a) DMF, 0 deg C, 1 h, 1b) r.t., 1 h, 2) DMF, r.t., pH 7, 3 d

With N-ethylmorpholine;; sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane; water;

Reference yield:

(S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)-6-((tert-butoxycarbonyl)amino)hexanoate (42362-08-3) → Benzyloxycarbonyl-L-phenylalanyl-Nε-tert-butyloxycarbonyl-L-lysyl-L-leucin-amid (149036-80-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / 1N NaOH / dioxane; H₂O / Ambient temperature

2: 1a) HOBt, DCC, 2) N-ethylmorpholine / 1a) DMF, 0 deg C, 1 h, 1b) r.t., 1 h, 2) DMF, r.t., pH 7, 3 d

With N-ethylmorpholine;; sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane; water;

Reference yield:

N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride (2389-48-2) → Benzyloxycarbonyl-L-phenylalanyl-Nε-tert-butyloxycarbonyl-L-lysyl-L-leucin-amid (149036-80-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1a) HOBt, DCC, 2) N-ethylmorpholine / 1a) DMF, 0 deg C, 1 h, 1b) r.t., 1 h, 2) DMF, r.t., pH 7, 3 d

2: 98 percent / 1N NaOH / dioxane; H₂O / Ambient temperature

3: 1a) HOBt, DCC, 2) N-ethylmorpholine / 1a) DMF, 0 deg C, 1 h, 1b) r.t., 1 h, 2) DMF, r.t., pH 7, 3 d

With N-ethylmorpholine;; sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane; water;

upstream raw materials:

H-L-Leu-NH₂

(S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)-6-((tert-butoxycarbonyl)amino)hexanoic acid

N-Cbz-L-Phe

(S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)-6-((tert-butoxycarbonyl)amino)hexanoate

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