3-[2-[1-(hydroxymethyl)cyclopropyl]-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-5-yl]benzonitrile

Base Information

Chemical Name:3-[2-[1-(hydroxymethyl)cyclopropyl]-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-5-yl]benzonitrile
CAS No.:1232333-03-7
Molecular Formula:C₁₈H₁₆N₄O₂
Molecular Weight:320.351
Hs Code.:

Synonyms:3-[2-[1-(hydroxymethyl)cyclopropyl]-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-5-yl]benzonitrile

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Chemical Property of 3-[2-[1-(hydroxymethyl)cyclopropyl]-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-5-yl]benzonitrile

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Technology Process of 3-[2-[1-(hydroxymethyl)cyclopropyl]-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-5-yl]benzonitrile

There total 1 articles about 3-[2-[1-(hydroxymethyl)cyclopropyl]-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-5-yl]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1232335-90-8
[1-(5-iodo-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropyl]methanol

: 497147-93-0
3-cyanopyridine-5-boronic acid

: 1232333-03-7
3-[2-[1-(hydroxymethyl)cyclopropyl]-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-5-yl]benzonitrile

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 80 ℃; for 18h;

Reference yield:

: 1232333-03-7
3-[2-[1-(hydroxymethyl)cyclopropyl]-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-5-yl]benzonitrile

: 1795-48-8
Isopropyl isocyanate

: 1232333-07-1
isopropyl-carbamic acid 1-[5-(3-cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl ester

Guidance literature:: With triethylamine; In acetonitrile; at 65 ℃; for 44h; Inert atmosphere;

Reference yield:

: 1192-63-8
1-pyrrolidinecarbonyl chloride

: 1232333-03-7
3-[2-[1-(hydroxymethyl)cyclopropyl]-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-5-yl]benzonitrile

: 1232333-05-9
pyrrolidine-1-carboxylic acid 1-[5-(3-cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl ester

Guidance literature:: 3-[2-[1-(hydroxymethyl)cyclopropyl]-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-5-yl]benzonitrile; With sodium hydride; In N,N-dimethyl-formamide; at 65 ℃; for 1h; Inert atmosphere;

1-pyrrolidinecarbonyl chloride; In N,N-dimethyl-formamide; at 65 ℃; for 1h; Inert atmosphere;