1-(4-chlorophenyl)-2-tosyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]-indole

Base Information

Chemical Name:1-(4-chlorophenyl)-2-tosyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]-indole
CAS No.:1416349-13-7
Molecular Formula:C₂₄H₂₁ClN₂O₂S
Molecular Weight:436.962
Hs Code.:

Synonyms:1-(4-chlorophenyl)-2-tosyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]-indole

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Chemical Property of 1-(4-chlorophenyl)-2-tosyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]-indole

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Technology Process of 1-(4-chlorophenyl)-2-tosyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]-indole

There total 4 articles about 1-(4-chlorophenyl)-2-tosyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1416349-25-1
N-(2-(1H-indol-2-yl)ethyl)-4-methylbenzenesulfonamide

: 104-88-1
4-chlorobenzaldehyde

: 1416349-13-7
1-(4-chlorophenyl)-2-tosyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]-indole

Guidance literature:: With silver hexafluoroantimonate; In 1,2-dichloro-ethane; at 25 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jo302068e

Reference yield: 72.0%

: 1416349-23-9
N-(4-(2-aminophenyl)but-3-yn-1-yl)-4-methylbenzenesulfonamide

: 104-88-1
4-chlorobenzaldehyde

: 1416349-13-7
1-(4-chlorophenyl)-2-tosyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]-indole

Guidance literature:: N-(4-(2-aminophenyl)but-3-yn-1-yl)-4-methylbenzenesulfonamide; With silver hexafluoroantimonate; chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I); In 1,2-dichloro-ethane; at 25 ℃; Inert atmosphere;

4-chlorobenzaldehyde; In 1,2-dichloro-ethane; at 25 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jo302068e

Reference yield:

: 161040-05-7
N-(but-3-yn-1-yl)-4-methylbenzenesulfonamide

: 1416349-13-7
1-(4-chlorophenyl)-2-tosyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]-indole

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride / 25 °C / Inert atmosphere

1.2: 6 h / 25 °C / Inert atmosphere

2.1: chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I); silver hexafluoroantimonate / 1,2-dichloro-ethane / 25 °C / Inert atmosphere

2.2: 4 h / 25 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; silver hexafluoroantimonate; chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I); triethylamine; In 1,2-dichloro-ethane; 1.1: |Sonogashira Cross-Coupling / 1.2: |Sonogashira Cross-Coupling / 2.2: |Pictet-Spengler Synthesis;
DOI:10.1021/jo302068e