2-[4-fluoro-3-(trifluoromethyl)phenyl]-5-[4-(1H-pyrrol-1-yl)phenyl]-1,3,4-oxadiazole

Base Information

Chemical Name:2-[4-fluoro-3-(trifluoromethyl)phenyl]-5-[4-(1H-pyrrol-1-yl)phenyl]-1,3,4-oxadiazole
CAS No.:1383714-87-1
Molecular Formula:C₁₉H₁₁F₄N₃O
Molecular Weight:373.309
Hs Code.:

Synonyms:2-[4-fluoro-3-(trifluoromethyl)phenyl]-5-[4-(1H-pyrrol-1-yl)phenyl]-1,3,4-oxadiazole

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Chemical Property of 2-[4-fluoro-3-(trifluoromethyl)phenyl]-5-[4-(1H-pyrrol-1-yl)phenyl]-1,3,4-oxadiazole

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Technology Process of 2-[4-fluoro-3-(trifluoromethyl)phenyl]-5-[4-(1H-pyrrol-1-yl)phenyl]-1,3,4-oxadiazole

There total 3 articles about 2-[4-fluoro-3-(trifluoromethyl)phenyl]-5-[4-(1H-pyrrol-1-yl)phenyl]-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1383714-79-1
C₁₉H₁₃F₄N₃O₂

: 1383714-87-1
2-[4-fluoro-3-(trifluoromethyl)phenyl]-5-[4-(1H-pyrrol-1-yl)phenyl]-1,3,4-oxadiazole

Guidance literature:: With phosphorus pentoxide; In N,N-dimethyl-formamide; at 20 ℃; for 4h; Reflux;
DOI:10.1007/s00044-012-0112-0

Reference yield:

: 112575-84-5
4-(1H-pyrrol-1-yl)benzoic acid hydrazide

: 1383714-87-1
2-[4-fluoro-3-(trifluoromethyl)phenyl]-5-[4-(1H-pyrrol-1-yl)phenyl]-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / Reflux

2: phosphorus pentoxide / N,N-dimethyl-formamide / 4 h / 20 °C / Reflux

With phosphorus pentoxide; In N,N-dimethyl-formamide;
DOI:10.1007/s00044-012-0112-0

Reference yield:

: 5044-37-1
1-(4-ethoxycarbonylphenyl)pyrrole

: 1383714-87-1
2-[4-fluoro-3-(trifluoromethyl)phenyl]-5-[4-(1H-pyrrol-1-yl)phenyl]-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 3 h / Reflux

2: N,N-dimethyl-formamide / Reflux

3: phosphorus pentoxide / N,N-dimethyl-formamide / 4 h / 20 °C / Reflux

With hydrazine hydrate; phosphorus pentoxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1007/s00044-012-0112-0