112575-84-5Relevant articles and documents
Design, synthesis, and evaluation of the antimycobacterial activity of 3-mercapto-1,2,4-triazole–pyrrole hybrids
Roman, Gheorghe,Bost?naru, Andra-Cristina,N?stas?, Valentin,Mare?, Mihai
, p. 531 - 546 (2019)
A series of 3-mercapto-1,2,4-triazole–pyrrole hybrids was designed as antimycobacterial agents by employing 5-(4-(1H-pyrrol-1-yl)phenyl)-4H-1,2,4-triazole-3-thiol as the scaffold onto which several types of moieties were introduced in the triazole ring at N-4 and N-2 and as substituents of the mercapto function. The aforementioned moieties are an allyl or a phenyl moiety at N-4; an aminomethyl group at N-2; or methyl, substituted benzyl, ethoxycarbonylmethyl, or substituted phenacyl at sulfur. Investigation of the compounds in the resulting library as growth inhibitors of Mycobacterium smegmatis showed that their minimum inhibitory concentration was higher than 64 mg/L.
Synthesis, biological evaluation and in silico molecular modeling of pyrrolyl benzohydrazide derivatives as enoyl ACP reductase inhibitors
Joshi, Shrinivas D.,Dixit, Sheshagiri R.,Kulkarni, Venkatarao H.,Lherbet, Christian,Nadagouda, Mallikarjuna N.,Aminabhavi, Tejraj M.
, p. 286 - 297 (2016/12/09)
In efforts to develop lead anti-TB compounds, a novel series of 19 pyrrolyl benzohydrazides were synthesized and screened to target enoyl-ACP reductase enzyme, which is one of the important enzymes involved in type II fatty acid biosynthetic pathway of M.
Synthesis and antimicrobial activities of some novel pyrrolyl pyrrolidine derivatives
Joshi, Shrinivas D.,Dixit, Sheshagiri R.,Sanjay, Khadela,Kulkarni, Venkatrao H.
, p. 61 - 64 (2019/01/21)
A series of N'-(4-(1H-pyrrol-1-yl)benzoyl)-5-oxo-1-substituted phenylpyrrolidine-3- carbohydrazides (VIIa-f) was synthesized by the reaction of 5-oxo-1-substituted phenylpyrrolidine-3-carboxylic acids (VIa-f) with 4-(1H-pyrrol-1-yl)benzoic acid hydrazide
