4-chloro-2-[2-(diethoxyphosphoryl)propionylamino]-4-methylbenzoic acid methyl ester

Base Information

Chemical Name:4-chloro-2-[2-(diethoxyphosphoryl)propionylamino]-4-methylbenzoic acid methyl ester
CAS No.:868526-78-7
Molecular Formula:C₁₅H₂₁ClNO₆P
Molecular Weight:377.762
Hs Code.:

Synonyms:4-chloro-2-[2-(diethoxyphosphoryl)propionylamino]-4-methylbenzoic acid methyl ester

Suppliers and Price of 4-chloro-2-[2-(diethoxyphosphoryl)propionylamino]-4-methylbenzoic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 4-chloro-2-[2-(diethoxyphosphoryl)propionylamino]-4-methylbenzoic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-chloro-2-[2-(diethoxyphosphoryl)propionylamino]-4-methylbenzoic acid methyl ester

There total 1 articles about 4-chloro-2-[2-(diethoxyphosphoryl)propionylamino]-4-methylbenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 5900-58-3
2-amino-4-chloro-benzoic acid methyl ester

: 30094-28-1
2-(diethylphosphono)propionic acid

: 868526-78-7
4-chloro-2-[2-(diethoxyphosphoryl)propionylamino]-4-methylbenzoic acid methyl ester

Guidance literature:: With dmap; diisopropyl-carbodiimide; In dichloromethane; at 0 - 23 ℃; for 28h;
DOI:10.1021/jm050523n

Reference yield: 48.0%

: 868526-78-7
4-chloro-2-[2-(diethoxyphosphoryl)propionylamino]-4-methylbenzoic acid methyl ester

: 104-88-1
4-chlorobenzaldehyde

: 4-chloro-2-{[(2E)-3-(4-chlorophenyl)-2-methylprop-2-enoyl]amino}benzoic acid methyl ester

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In tetrahydrofuran; at 23 ℃; for 12h;
DOI:10.1021/jm050523n

Reference yield:

: 868526-78-7
4-chloro-2-[2-(diethoxyphosphoryl)propionylamino]-4-methylbenzoic acid methyl ester

: 4-Chloro-2-[3-(4-chloro-phenyl)-2-methyl-acryloylamino]-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 48 percent / LiCl; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 12 h / 23 °C

2: 91 percent / aq. LiOH / tetrahydrofuran / 12 h / 20 °C

With lithium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In tetrahydrofuran; 1: Horner-Emmons coupling;
DOI:10.1021/jm050523n