2-(DIETHYLPHOSPHONO)PROPANOIC ACID

Base Information

• Chemical Name: 2-(DIETHYLPHOSPHONO)PROPANOIC ACID
• CAS No.: 30094-28-1
• Molecular Formula: C7H15 O5 P
• Molecular Weight: 210.167
• Hs Code.: 2931900090
• Mol file: 30094-28-1.mol

Synonyms:Propionicacid, 2-phosphono-, P,P-diethyl ester (8CI); 2-(Diethoxyphosphinyl)propanoicacid; 2-(Diethoxyphosphoryl)propionic acid; 2-(Diethylphosphono)propionic acid;Diethyl 1-carboxyethylphosphonate; a-(Diethylphosphono)propionic acid

Chemical Property of 2-(DIETHYLPHOSPHONO)PROPANOIC ACID

Chemical Property:

• Melting Point: >70 °C
• Boiling Point: 125 °C(Press: 0.2 Torr)
• PKA: 3.54±0.10(Predicted)
• PSA: 82.64000
• Density: 1.194±0.06 g/cm3(Predicted)
• LogP: 1.72560

Purity/Quality:

99%, ^*data from raw suppliers

2-(DIETHYLPHOSPHONO)PROPANOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(DIETHYLPHOSPHONO)PROPANOIC ACID

There total 6 articles about 2-(DIETHYLPHOSPHONO)PROPANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 2-diethoxyphosphorylpropionate (3699-66-9) → 2-(diethylphosphono)propionic acid (30094-28-1)

Guidance literature:

With sodium hydroxide; at 0 - 20 ℃;

DOI:10.1021/jo800973e

Reference yield: 84.0%

trimethylsilyl 2-diethylphosphonopropionate (84162-39-0) → 2-(diethylphosphono)propionic acid (30094-28-1)

Guidance literature:

With hydrogenchloride;

DOI:10.1016/0040-4020(89)80132-2

Reference yield: 31.0%

2-Bromopropionic acid (598-72-1,10327-08-9) + phosphonic acid diethyl ester (762-04-9) → 2-(diethylphosphono)propionic acid (30094-28-1)

Guidance literature:

With sodium hydride; In 1,2-dimethoxyethane; for 96h;

DOI:10.1021/jo00325a016

upstream raw materials:

tert-butyl α-(diethoxyphosphinyl)propionate

ethylphosphonic acid diethyl ester

carbon dioxide

trimethylsilyl 2-diethylphosphonopropionate

Downstream raw materials:

trans-3-(3,4-methylenedioxyphenyl)-2-methylacrylic acid

3,5,5-Trimethyl-5,6-dihydro-2H-pyran-2-on

(S)-2-[2-(Diethoxy-phosphoryl)-propionyloxy]-pentanoic acid benzyl ester

2-cyclohexylidenepropanoic acid

Refernces

• 1、 Katsumura, Shigeo,Isoe, Sachiniko. "AN EFFICIENT SYNTHESIS OF JOLKINOLIDE E INVOLVING THE BUTENOLIDE RING FORMATION". . p. 1689 - 1692. Retrieved 1982.
• 2、 Luke, George P.,Seekamp, Christopher K.,Wang, Zhe-Qing,Chenard, Bertrand L.. "An efficient preparation of β-aryl-β-ketophosphonates by the TFAA/H3PO4-mediated acylation of arenes with phosphonoacetic acids". . p. 6397 - 6400. Retrieved 2008/12/21.