2-(2,5-Difluoro-4-methoxyphenyl)-6-methoxynaphthalene

Base Information

Chemical Name:2-(2,5-Difluoro-4-methoxyphenyl)-6-methoxynaphthalene
CAS No.:550998-21-5
Molecular Formula:C₁₈H₁₄F₂O₂
Molecular Weight:300.305
Hs Code.:
DSSTox Substance ID:DTXSID301214495

Synonyms:2-(2,5-difluoro-4-methoxyphenyl)-6-methoxynaphthalene;SCHEMBL5981432;RZCNLTHMEAUSJJ-UHFFFAOYSA-N;DTXSID301214495;550998-21-5

Suppliers and Price of 2-(2,5-Difluoro-4-methoxyphenyl)-6-methoxynaphthalene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2,5-Difluoro-4-methoxyphenyl)-6-methoxynaphthalene

Chemical Property:

XLogP3:4.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:300.09618601
Heavy Atom Count:22
Complexity:365

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC2=C(C=C1)C=C(C=C2)C3=CC(=C(C=C3F)OC)F

Technology Process of 2-(2,5-Difluoro-4-methoxyphenyl)-6-methoxynaphthalene

There total 3 articles about 2-(2,5-Difluoro-4-methoxyphenyl)-6-methoxynaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.2%

: 202865-60-9
1-bromo-2,5-difluoro-4-methoxybenzene

: 156641-98-4
(6-methoxy-2-naphthalene)boronic acid

: 550998-21-5
2-(2,5-difluoro-4-methoxyphenyl)-6-methoxynaphthalene

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; at 85 ℃;
DOI:10.1021/jm058173s

Reference yield:

: 5111-65-9
2-Bromo-6-methoxynaphthalene

: 550998-21-5
2-(2,5-difluoro-4-methoxyphenyl)-6-methoxynaphthalene

Guidance literature:: Multi-step reaction with 2 steps

1.1: sec-BuLi / hexane; tetrahydrofuran / -78 °C

1.2: triisopropyl borate / hexane; tetrahydrofuran

1.3: 100 percent / aq. HCl / hexane; tetrahydrofuran / 0.17 h

2.1: 94.2 percent / aq. Na₂CO₃; Pd[P(Ph)3]4 / 1,2-dimethoxy-ethane / 85 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sec.-butyllithium; sodium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; 2.1: Suzuki coupling;
DOI:10.1021/jm058173s