3-bromo-1-(3-chloropyridin-2-yl)-N-(2-formyl-6-methylphenyl)-1H-pyrazole-5-carboxamide

Base Information

• Chemical Name: 3-bromo-1-(3-chloropyridin-2-yl)-N-(2-formyl-6-methylphenyl)-1H-pyrazole-5-carboxamide
• CAS No.: 1417565-43-5
• Molecular Formula: C₁₇H₁₂BrClN₄O₂
• Molecular Weight: 419.665
• Mol file: 1417565-43-5.mol

Synonyms:3-bromo-1-(3-chloropyridin-2-yl)-N-(2-formyl-6-methylphenyl)-1H-pyrazole-5-carboxamide

Chemical Property of 3-bromo-1-(3-chloropyridin-2-yl)-N-(2-formyl-6-methylphenyl)-1H-pyrazole-5-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-bromo-1-(3-chloropyridin-2-yl)-N-(2-formyl-6-methylphenyl)-1H-pyrazole-5-carboxamide

There total 3 articles about 3-bromo-1-(3-chloropyridin-2-yl)-N-(2-formyl-6-methylphenyl)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid (500011-86-9) + 2-amino-3-methylbenzaldehyde (84902-24-9) → 3-bromo-1-(3-chloropyridin-2-yl)-N-(2-formyl-6-methylphenyl)-1H-pyrazole-5-carboxamide (1417565-43-5)

Guidance literature:

3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 2h;

2-amino-3-methylbenzaldehyde; With pyridine; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2012.11.045

Reference yield:

2-amino-3-methylbenzyl alcohol (57772-50-6) → 3-bromo-1-(3-chloropyridin-2-yl)-N-(2-formyl-6-methylphenyl)-1H-pyrazole-5-carboxamide (1417565-43-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: manganese(IV) oxide / dichloromethane / 20 °C

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C

2.2: 2 h / 0 - 20 °C

With manganese(IV) oxide; oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.11.045

Reference yield:

3-methylantranilic acid (4389-45-1) → 3-bromo-1-(3-chloropyridin-2-yl)-N-(2-formyl-6-methylphenyl)-1H-pyrazole-5-carboxamide (1417565-43-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

2.1: manganese(IV) oxide / dichloromethane / 20 °C

3.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C

3.2: 2 h / 0 - 20 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; oxalyl dichloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.11.045

upstream raw materials:

3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid

2-amino-3-methylbenzaldehyde

3-methylantranilic acid

2-amino-3-methylbenzyl alcohol

Downstream raw materials:

C₁₇H₁₁BrClN₅O

3-bromo-1-(3-chloropyridin-2-yl)-N-(2-formyl-6-methyl-4-nitrophenyl)-1H-pyrazole-5-carboxamide

C₁₇H₁₀BrClN₆O₃