1,3-dihydro-1-methyl-3-amino-5-(3-methoxyphenyl)-2H-1,4-benzodiazepine-2-one

Base Information

Chemical Name:1,3-dihydro-1-methyl-3-amino-5-(3-methoxyphenyl)-2H-1,4-benzodiazepine-2-one
CAS No.:168762-90-1
Molecular Formula:C₁₇H₁₇N₃O₂
Molecular Weight:295.341
Hs Code.:

Synonyms:1,3-dihydro-1-methyl-3-amino-5-(3-methoxyphenyl)-2H-1,4-benzodiazepine-2-one

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Chemical Property of 1,3-dihydro-1-methyl-3-amino-5-(3-methoxyphenyl)-2H-1,4-benzodiazepine-2-one

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Technology Process of 1,3-dihydro-1-methyl-3-amino-5-(3-methoxyphenyl)-2H-1,4-benzodiazepine-2-one

There total 1 articles about 1,3-dihydro-1-methyl-3-amino-5-(3-methoxyphenyl)-2H-1,4-benzodiazepine-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: C₂₄H₂₁N₃O₄

: 168762-90-1
1,3-dihydro-1-methyl-3-amino-5-(3-methoxyphenyl)-2H-1,4-benzodiazepine-2-one

Guidance literature:: With water; hydrogen bromide; acetic acid; at 20 ℃; for 1h;

Reference yield:

: 168762-90-1
1,3-dihydro-1-methyl-3-amino-5-(3-methoxyphenyl)-2H-1,4-benzodiazepine-2-one

: 195510-98-6
(3-{3-[5-(3-methoylphenyl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]ureido}benzyloxycarbonylamino)ectic acid

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 3 h

2: aq. NaOH / methanol / 2 h / 0 °C

With sodium hydroxide; triethylamine; In methanol; dichloromethane;
DOI:10.1016/S0968-0896(97)00074-6

Reference yield:

: 168762-90-1
1,3-dihydro-1-methyl-3-amino-5-(3-methoxyphenyl)-2H-1,4-benzodiazepine-2-one

: ({2-[3-(3-piperidin-1-ylmethylphenoxy)propylcarbamoyl]ethylcarbamoyl}methyl)carbamic acid 3-{3-[5-(3-hydroxyphenyl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]ureido}benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 3 h

2: aq. NaOH / methanol / 2 h / 0 °C

3: 1-hydroxybenzotriazol, Et₃N, 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride / dimethylformamide / 16 h / Ambient temperature

4: 40 percent / BBr₃ / CH₂Cl₂ / 3 h / -30 °C

With sodium hydroxide; boron tribromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)00074-6