(3-{3-[5-(3-methoylphenyl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]ureido}benzyloxycarbonylamino)ectic acid

Base Information

• Chemical Name: (3-{3-[5-(3-methoylphenyl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]ureido}benzyloxycarbonylamino)ectic acid
• CAS No.: 195510-98-6
• Molecular Formula: C₂₈H₂₇N₅O₇
• Molecular Weight: 545.552

Synonyms:(3-{3-[5-(3-methoylphenyl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]ureido}benzyloxycarbonylamino)ectic acid

Chemical Property of (3-{3-[5-(3-methoylphenyl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]ureido}benzyloxycarbonylamino)ectic acid

Chemical Property:

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Technology Process of (3-{3-[5-(3-methoylphenyl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]ureido}benzyloxycarbonylamino)ectic acid

There total 3 articles about (3-{3-[5-(3-methoylphenyl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]ureido}benzyloxycarbonylamino)ectic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-{3-[5-(3-methoylphenyl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]ureido}benzyloxycarbonylamino)ectic acid ethyl ester (195510-97-5) → (3-{3-[5-(3-methoylphenyl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]ureido}benzyloxycarbonylamino)ectic acid (195510-98-6)

Guidance literature:

With sodium hydroxide; In methanol; at 0 ℃; for 2h;

DOI:10.1016/S0968-0896(97)00074-6

Reference yield:

1,3-dihydro-1-methyl-3-amino-5-(3-methoxyphenyl)-2H-1,4-benzodiazepine-2-one (168762-90-1) → (3-{3-[5-(3-methoylphenyl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]ureido}benzyloxycarbonylamino)ectic acid (195510-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 3 h

2: aq. NaOH / methanol / 2 h / 0 °C

With sodium hydroxide; triethylamine; In methanol; dichloromethane;

DOI:10.1016/S0968-0896(97)00074-6

Reference yield:

(3-Isocyanato-benzyloxycarbonylamino)-acetic acid ethyl ester → (3-{3-[5-(3-methoylphenyl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]ureido}benzyloxycarbonylamino)ectic acid (195510-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 3 h

2: aq. NaOH / methanol / 2 h / 0 °C

With sodium hydroxide; triethylamine; In methanol; dichloromethane;

DOI:10.1016/S0968-0896(97)00074-6

upstream raw materials:

(3-{3-[5-(3-methoylphenyl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]ureido}benzyloxycarbonylamino)ectic acid ethyl ester

1,3-dihydro-1-methyl-3-amino-5-(3-methoxyphenyl)-2H-1,4-benzodiazepine-2-one

Downstream raw materials:

({2-[3-(3-piperidin-1-ylmethylphenoxy)propylcarbamoyl]ethylcarbamoyl}methyl)carbamic acid 3-{3-[5-(3-methoylphenyl)-1-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]ureido}benzyl ester

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