Chemical Property of 6-Fluoro-3-((E)-2-pyridin-3-yl-vinyl)-1H-indole
Chemical Property:
- Boiling Point:431.2±35.0 °C(Predicted)
- PKA:15.92±0.30(Predicted)
- PSA：28.68000
- Density:1.305±0.06 g/cm3(Predicted)
- LogP:3.87240
- Storage Temp.:2-8°C
- Solubility.:DMSO: ≥10mg/mL
- XLogP3:3.3
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:2
- Exact Mass:238.09062652
- Heavy Atom Count:18
- Complexity:305
- Purity/Quality:
-
99%, *data from raw suppliers
680C91 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xi
- Statements:
41
- Safety Statements:
26-39
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC(=CN=C1)C=CC2=CNC3=C2C=CC(=C3)F
- Isomeric SMILES:C1=CC(=CN=C1)/C=C/C2=CNC3=C2C=CC(=C3)F
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Description
680C91 (163239-22-3) is a potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) Ki=42 nM).1,2?Displays no activity against indoleamine 2,3-dioxygenase, MAO-A and B and does not effect serotonin uptake. Elevates CSF tryptophan by up to 260% and CSF serotonin by 170% of basal.2?TDO inhibition by 680C91 in glioma cells blocked the release of kynurenine (Cat.# 10-2666), an endogenous tumor promoting AHR ligand.4
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Uses
680C91 has been used:as a tryptophan 2,3 dioxygenase (TDO) inhibitor to study its effects on the pigmentation in Doryteuthis pealeii embryosas a TDO inhibitor to study its effects on esophageal squamous cell carcinoma in xenograft tumor assayas a tryptophan 2,3 dioxygenase 2 (TDO2) inhibitor to study its effects on toxic fragment formation in human embryonic kidney cells
