5-[6-(2,2':6',2''-terpyridine-4'-carboxamido)hexanamido]-N,N'-bis[6-(3,3-dimethylbutanamido)pyridin-2-yl]isophthalamide

Base Information

• Chemical Name: 5-[6-(2,2':6',2''-terpyridine-4'-carboxamido)hexanamido]-N,N'-bis[6-(3,3-dimethylbutanamido)pyridin-2-yl]isophthalamide
• CAS No.: 1332851-03-2
• Molecular Formula: C₅₂H₅₇N₁₁O₆
• Molecular Weight: 932.095
• Mol file: 1332851-03-2.mol

Synonyms:5-[6-(2,2':6',2''-terpyridine-4'-carboxamido)hexanamido]-N,N'-bis[6-(3,3-dimethylbutanamido)pyridin-2-yl]isophthalamide

Chemical Property of 5-[6-(2,2':6',2''-terpyridine-4'-carboxamido)hexanamido]-N,N'-bis[6-(3,3-dimethylbutanamido)pyridin-2-yl]isophthalamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[6-(2,2':6',2''-terpyridine-4'-carboxamido)hexanamido]-N,N'-bis[6-(3,3-dimethylbutanamido)pyridin-2-yl]isophthalamide

There total 5 articles about 5-[6-(2,2':6',2''-terpyridine-4'-carboxamido)hexanamido]-N,N'-bis[6-(3,3-dimethylbutanamido)pyridin-2-yl]isophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

6-(2,2':6',2''-terpyridine-4'-carboxamido)hexanoic acid (1332851-02-1) + 5-amino-N,N'-bis[6-(3,3-dimethylbutyrylamino)pyridin-2-yl]-isophthalamide (717111-10-9) → 5-[6-(2,2':6',2''-terpyridine-4'-carboxamido)hexanamido]-N,N'-bis[6-(3,3-dimethylbutanamido)pyridin-2-yl]isophthalamide (1332851-03-2)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 50 ℃; for 14h; Sonication;

DOI:10.1002/chem.201100171

Reference yield:

6-(2,2':6',2''-terpyridine-4'-carboxamido)hexanoic acid methyl ester (1332851-01-0) → 5-[6-(2,2':6',2''-terpyridine-4'-carboxamido)hexanamido]-N,N'-bis[6-(3,3-dimethylbutanamido)pyridin-2-yl]isophthalamide (1332851-03-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / 14 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 14 h / 50 °C / Sonication

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran;

DOI:10.1002/chem.201100171

Reference yield:

methyl 6-aminocaproate hydrochloride (1926-80-3) → 5-[6-(2,2':6',2''-terpyridine-4'-carboxamido)hexanamido]-N,N'-bis[6-(3,3-dimethylbutanamido)pyridin-2-yl]isophthalamide (1332851-03-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 h / 0 - 50 °C / Sonication

2: sodium hydroxide / 14 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 14 h / 50 °C / Sonication

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1002/chem.201100171

upstream raw materials:

6-(2,2':6',2''-terpyridine-4'-carboxamido)hexanoic acid methyl ester

6-(2,2':6',2''-terpyridine-4'-carboxamido)hexanoic acid

5-amino-N,N'-bis[6-(3,3-dimethylbutyrylamino)pyridin-2-yl]-isophthalamide

methyl 6-aminocaproate hydrochloride