Technology Process of (E)-4-(3-(3,3,6,6-tetramethylcyclohex-1-enyl)acryloyl)piperazine-1-carboxamide
There total 7 articles about (E)-4-(3-(3,3,6,6-tetramethylcyclohex-1-enyl)acryloyl)piperazine-1-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(E)-3-(3,3,6,6-tetramethylcyclohex-1-enyl)acrylic acid;
With
N-ethyl-N,N-diisopropylamine; HATU;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.5h;
piperazine-1-carboxamide trifluoroacetate salt;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium diisopropyl amide / tetrahydrofuran; diethyl ether / 1 h / -78 °C
1.2: 1 h / -78 °C
2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran / 0.5 h / -72 °C / Inert atmosphere
3.1: acetic anhydride; acetyl chloride / acetic acid / 2 h / Reflux
4.1: water; sodium hydroxide / methanol / 2 h / Reflux
4.2: pH 2 - 3
5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C
5.2: 3 h / 20 °C
With
water; acetic anhydride; N-ethyl-N,N-diisopropylamine; acetyl chloride; sodium bis(2-methoxyethoxy)aluminium dihydride; HATU; sodium hydroxide; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; diethyl ether; acetic acid; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: water; sodium hydroxide / methanol / 2 h / Reflux
1.2: pH 2 - 3
2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C
2.2: 3 h / 20 °C
With
water; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide;
In
methanol; N,N-dimethyl-formamide;
