Technology Process of (E)-methyl 3-(3,3,6,6-tetramethylcyclohex-1-enyl)acrylate
There total 4 articles about (E)-methyl 3-(3,3,6,6-tetramethylcyclohex-1-enyl)acrylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
acetic anhydride; acetyl chloride;
In
acetic acid;
for 2h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 6 steps
3.1: boron trifluoride diethyl etherate / tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere
4.1: lithium diisopropyl amide / tetrahydrofuran; diethyl ether / 1 h / -78 °C
4.2: 1 h / -78 °C
5.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran / 0.5 h / -72 °C / Inert atmosphere
6.1: acetic anhydride; acetyl chloride / acetic acid / 2 h / Reflux
With
boron trifluoride diethyl etherate; acetic anhydride; acetyl chloride; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; acetic acid;
- Guidance literature:
-
Multi-step reaction with 5 steps
2.1: boron trifluoride diethyl etherate / tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere
3.1: lithium diisopropyl amide / tetrahydrofuran; diethyl ether / 1 h / -78 °C
3.2: 1 h / -78 °C
4.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran / 0.5 h / -72 °C / Inert atmosphere
5.1: acetic anhydride; acetyl chloride / acetic acid / 2 h / Reflux
With
boron trifluoride diethyl etherate; acetic anhydride; acetyl chloride; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; acetic acid;
