[1,2-13C₂]Cbz-Gly-OtBu

Base Information

Chemical Name:[1,2-13C₂]Cbz-Gly-OtBu
CAS No.:1391760-58-9
Molecular Formula:C₁₄H₁₉NO₄
Molecular Weight:267.287
Hs Code.:

Synonyms:[1,2-13C₂]Cbz-Gly-OtBu

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Chemical Property of [1,2-13C₂]Cbz-Gly-OtBu

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Technology Process of [1,2-13C₂]Cbz-Gly-OtBu

There total 2 articles about [1,2-13C₂]Cbz-Gly-OtBu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 80058-03-3
[1,2-13C₂]Cbz-Gly-OH

: 115-11-7,15220-85-6
isobutene

: 1391760-58-9
[1,2-13C₂]Cbz-Gly-OtBu

Guidance literature:: With sulfuric acid; In dichloromethane; at -40 - 50 ℃; for 48h;
DOI:10.1039/c2ob07157f

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1391760-58-9
[1,2-13C₂]Cbz-Gly-OtBu

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water / 2 h / 0 - 20 °C

2: sulfuric acid / dichloromethane / 48 h / -40 - 50 °C

With sulfuric acid; sodium hydroxide; In dichloromethane; water;
DOI:10.1039/c2ob07157f

Reference yield:

: 1391760-58-9
[1,2-13C₂]Cbz-Gly-OtBu

: 1391760-62-5
[1,2-13C₂]Cbz-Glu(Me)-OtBu

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 16 h / 20 °C

2.1: dichloromethane / 24 h / 20 °C / Darkness

3.1: cesiumhydroxide monohydrate; (1S,2S,4S,5R)-2-((R)-(allyloxy)(quinolin-4-yl)methyl)-1-(anthracen-9-ylmethyl)-5-vinylquinuclidin-1-ium bromide / dichloromethane / 0.08 h / -78 °C

3.2: 1.67 h / -78 °C

4.1: citric acid / tetrahydrofuran; water / 8 h / 0 - 20 °C

5.1: dichloromethane / 0.08 h / 0 °C

5.2: 3 h / 20 °C

With (1S,2S,4S,5R)-2-((R)-(allyloxy)(quinolin-4-yl)methyl)-1-(anthracen-9-ylmethyl)-5-vinylquinuclidin-1-ium bromide; cesiumhydroxide monohydrate; palladium 10% on activated carbon; hydrogen; citric acid; In tetrahydrofuran; dichloromethane; water; ethyl acetate;
DOI:10.1039/c2ob07157f