methyl 3(R)-[[1-(benzyloxycarbonyl)-2(S)-pyrrolidinylmethyl]amino]-2-oxo-1-pyrrolidineacetate

Base Information

Chemical Name:methyl 3(R)-[[1-(benzyloxycarbonyl)-2(S)-pyrrolidinylmethyl]amino]-2-oxo-1-pyrrolidineacetate
CAS No.:644996-20-3
Molecular Formula:C₂₀H₂₇N₃O₅
Molecular Weight:389.451
Hs Code.:

Synonyms:methyl 3(R)-[[1-(benzyloxycarbonyl)-2(S)-pyrrolidinylmethyl]amino]-2-oxo-1-pyrrolidineacetate

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Chemical Property of methyl 3(R)-[[1-(benzyloxycarbonyl)-2(S)-pyrrolidinylmethyl]amino]-2-oxo-1-pyrrolidineacetate

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Technology Process of methyl 3(R)-[[1-(benzyloxycarbonyl)-2(S)-pyrrolidinylmethyl]amino]-2-oxo-1-pyrrolidineacetate

There total 2 articles about methyl 3(R)-[[1-(benzyloxycarbonyl)-2(S)-pyrrolidinylmethyl]amino]-2-oxo-1-pyrrolidineacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 71461-30-8
(S)-2-formylpyrrolidine-1-carboxylic acid benzyl ester

: ((R)-3-Amino-2-oxo-pyrrolidin-1-yl)-acetic acid methyl ester; hydrochloride

: 644996-20-3
methyl 3(R)-[[1-(benzyloxycarbonyl)-2(S)-pyrrolidinylmethyl]amino]-2-oxo-1-pyrrolidineacetate

Guidance literature:: (S)-2-formylpyrrolidine-1-carboxylic acid benzyl ester; ((R)-3-Amino-2-oxo-pyrrolidin-1-yl)-acetic acid methyl ester; hydrochloride; With 4 A molecular sieve; In methanol; at 20 ℃; for 4h;

With sodium cyanoborohydride; In methanol; at 20 ℃; for 144h;
DOI:10.1016/S0968-0896(03)00396-1

Reference yield:

: 114200-39-4
3(R)--2-oxo-1-pyrrolidineacetic acid methyl ester

: 644996-20-3
methyl 3(R)-[[1-(benzyloxycarbonyl)-2(S)-pyrrolidinylmethyl]amino]-2-oxo-1-pyrrolidineacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: HCl / dioxane

2.1: molecular sieves (4 Angstroem) / methanol / 4 h / 20 °C

2.2: 0.86 g / spdoim cyanoborohydride / methanol / 144 h / 20 °C

With hydrogenchloride; 4 A molecular sieve; In 1,4-dioxane; methanol;
DOI:10.1016/S0968-0896(03)00396-1