3(R)-[[1-(benzyloxycarbonyl)-2(S)-pyrrolidinylmethyl]amino]-2-oxo-1-pyrrolidineacetamide

Base Information

Chemical Name:3(R)-[[1-(benzyloxycarbonyl)-2(S)-pyrrolidinylmethyl]amino]-2-oxo-1-pyrrolidineacetamide
CAS No.:644996-21-4
Molecular Formula:C₁₉H₂₆N₄O₄
Molecular Weight:374.44
Hs Code.:

Synonyms:3(R)-[[1-(benzyloxycarbonyl)-2(S)-pyrrolidinylmethyl]amino]-2-oxo-1-pyrrolidineacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3(R)-[[1-(benzyloxycarbonyl)-2(S)-pyrrolidinylmethyl]amino]-2-oxo-1-pyrrolidineacetamide

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Technology Process of 3(R)-[[1-(benzyloxycarbonyl)-2(S)-pyrrolidinylmethyl]amino]-2-oxo-1-pyrrolidineacetamide

There total 2 articles about 3(R)-[[1-(benzyloxycarbonyl)-2(S)-pyrrolidinylmethyl]amino]-2-oxo-1-pyrrolidineacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 644996-20-3
methyl 3(R)-[[1-(benzyloxycarbonyl)-2(S)-pyrrolidinylmethyl]amino]-2-oxo-1-pyrrolidineacetate

: 644996-21-4
3(R)-[[1-(benzyloxycarbonyl)-2(S)-pyrrolidinylmethyl]amino]-2-oxo-1-pyrrolidineacetamide

Guidance literature:: With ammonia; In methanol;
DOI:10.1016/S0968-0896(03)00396-1

Reference yield:

: 114200-39-4
3(R)--2-oxo-1-pyrrolidineacetic acid methyl ester

: 644996-21-4
3(R)-[[1-(benzyloxycarbonyl)-2(S)-pyrrolidinylmethyl]amino]-2-oxo-1-pyrrolidineacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: HCl / dioxane

2.1: molecular sieves (4 Angstroem) / methanol / 4 h / 20 °C

2.2: 0.86 g / spdoim cyanoborohydride / methanol / 144 h / 20 °C

3.1: 86 percent / ammonia / methanol

With hydrogenchloride; 4 A molecular sieve; ammonia; In 1,4-dioxane; methanol;
DOI:10.1016/S0968-0896(03)00396-1