Technology Process of tert-butyl 2,2-dimethyl-5-(4-(4-butylbenzyl)phenethyl)-1,3-dioxan-5-ylcarbamate
There total 4 articles about tert-butyl 2,2-dimethyl-5-(4-(4-butylbenzyl)phenethyl)-1,3-dioxan-5-ylcarbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); potassium carbonate;
In
1,4-dioxane;
for 12h;
Inert atmosphere;
Reflux;
DOI:10.1016/j.tet.2013.02.030
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate / tetrahydrofuran; N,N-dimethyl-formamide / 6 h / Reflux
2: palladium 10% on activated carbon; hydrogen / methanol / 8 h / 20 °C
3: dibenzoyl peroxide; tert.-butylnitrite / acetonitrile / 5 h / 20 °C
4: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 12 h / Inert atmosphere; Reflux
With
tetrakis(triphenylphosphine) palladium(0); tert.-butylnitrite; palladium 10% on activated carbon; hydrogen; potassium carbonate; dibenzoyl peroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; acetonitrile;
4: |Suzuki Coupling;
DOI:10.1016/j.tet.2013.02.030
- Guidance literature:
-
Multi-step reaction with 3 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 8 h / 20 °C
2: dibenzoyl peroxide; tert.-butylnitrite / acetonitrile / 5 h / 20 °C
3: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 12 h / Inert atmosphere; Reflux
With
tetrakis(triphenylphosphine) palladium(0); tert.-butylnitrite; palladium 10% on activated carbon; hydrogen; potassium carbonate; dibenzoyl peroxide;
In
1,4-dioxane; methanol; acetonitrile;
3: |Suzuki Coupling;
DOI:10.1016/j.tet.2013.02.030