364631-73-2

Basic information

• Product Name: tert-Butyl (5-forMyl-2,2-diMethyl-1,3-dioxan-5-yl)carbaMate
• Synonyms: tert-Butyl (5-forMyl-2,2-diMethyl-1,3-dioxan-5-yl)carbaMate
• CAS NO: 364631-73-2
• Molecular Formula: C₁₂H₂₁NO₅
• Molecular Weight: 259.29884
• Mol File: 364631-73-2.mol
• Article Data: 16

Chemical Properties

• Melting Point: 116-119℃ (ethyl ether hexane )
• Appearance: /
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: tert-Butyl (5-forMyl-2,2-diMethyl-1,3-dioxan-5-yl)carbaMate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl (5-forMyl-2,2-diMethyl-1,3-dioxan-5-yl)carbaMate(364631-73-2)
• EPA Substance Registry System: tert-Butyl (5-forMyl-2,2-diMethyl-1,3-dioxan-5-yl)carbaMate(364631-73-2)

Safety Data

• Hazardous Substances Data: 364631-73-2(Hazardous Substances Data)

Usage

General Description

Tert-Butyl (5-formyl-2,2-dimethyl-1,3-dioxan-5-yl)carbamate is a chemical compound with the molecular formula C12H23NO4. It is a carbamate derivative, which is commonly used in chemical synthesis and pharmaceutical research. tert-Butyl (5-forMyl-2,2-diMethyl-1,3-dioxan-5-yl)carbaMate is characterized by a tert-butyl substituent attached to the nitrogen atom of the carbamate group, and a 5-formyl-2,2-dimethyl-1,3-dioxan-5-yl moiety. It is notable for its potential application in the development of pharmaceutical drugs and other bioactive compounds due to its unique structure and reactivity. Additionally, it may have uses as a reagent in organic chemistry reactions, and its properties make it a valuable tool for furthering scientific research in various fields.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 77-76-9 2,2-dimethoxy-propane 
• 77-86-1 2-amino-2-hydroxymethyl-1,3-propanediol 
• 146651-71-0 N-(tert-butyloxycarbonyl)-2-amino-2-(hydroxymethyl)propane-1,3-diol 
• 53104-32-8 (5-amino-2,2-dimethyl-1,3-dioxan-5-yl)methanol 
• 364631-72-1 tert-butyl N-[5-(hydroxymethyl)-2,2-dimethyl-1,3-dioxan-5-yl]carbamate 

Downstream Products

• 1004539-23-4 (E)-tert-butyl (5-{4-[methoxy(methyl)carbamoyl]styryl}-2,2-dimethyl-1,3-dioxan-5-yl)carbamate 
• 942399-89-5 (E)-{2,2-dimethyl-5-[2-(4-heptyloxy-3-trifluoromethylphenyl)vinyl]-1,3-dioxan-5-yl}carbamic acid tert-butyl ester 
• 1093172-26-9 C₂₇H₃₂F₃NO₅ 
• 1464782-22-6 C₂₃H₂₉NO₅ 
• 1464782-21-5 C₁₆H₂₅NO₃ 
• 1464782-05-5 C₂₁H₃₃NO₅ 
• 1427308-40-4 C₁₉H₂₆N₂O₆ 
• 885605-36-7 5-(tert-butyloxycarbonylamino)-2,2-dimethyl-5-(4-octylphenethyl)-1,3-dioxane 
• 1427308-50-6 C₂₇H₄₃NO₄ 
• 1427308-46-0 (E)-tert-butyl 2,2-dimethyl-5-(4-(4-octylstyryl)phenethyl)-1,3-dioxan-5-ylcarbamate 
• 1427308-45-9 (E)-tert-butyl 5-(4-(4-hexylstyryl)phenethyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate 

Relevant articles and documents

Construction of Quaternary Carbon Stereocenter of α-Tertiary Amine through Remote C-H Functionalization of Tris Derivatives: Enantioselective Total Synthesis of Myriocin

We describe the development of a strategy for the construction of the quaternary carbon stereocenter of α-tertiary amines. This strategy highlights a site-selective C-H functionalization involving an alkoxy-radical-triggered 1,5-hydrogen transfer (1,5-HAT

Synthesis and evaluation of fluorinated fingolimod (FTY720) analogues for sphingosine-1-phosphate receptor molecular imaging by positron emission tomography

Sphingosine-1-phosphate (S1P) is a lysophospholipid that evokes a variety of biological responses via stimulation of a set of cognate G-protein coupled receptors (GPCRs): S1P1-S1P5. S1P and its receptors (S1PRs) play important roles in the immune, cardiovascular, and central nervous systems and have also been implicated in carcinogenesis. Recently, the S1P analogue Fingolimod (FTY720) has been approved for the treatment of patients with relapsing multiple sclerosis. This work presents the synthesis of various fluorinated structural analogues of FTY720, their in vitro and in vivo biological testing, and their development and application as [18F]radiotracers for the study of S1PR biodistribution and imaging in mice using small-animal positron emission tomography (PET).

NEW LIGANDS FOR TARGETING OF S1P RECEPTORS FOR IN VIVO IMAGING AND TREATMENT OF DISEASES

The present invention relates to novel compounds of formulae (I) and (II) which are useful in the prevention, treatment and diagnosis, in vivo diagnosis of diseases or disorders related to S1P receptors, in particular, in diseases which are connected to the regulatory function of sphingosine-1-phosphate (S1P) and its analogues, such as inflammation, pain, autoimmune diseases and cardiovascular diseases.