(Z)-2-((methylsulfonamido)(benzylsulfanyl)methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid

Base Information

Chemical Name:(Z)-2-((methylsulfonamido)(benzylsulfanyl)methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid
CAS No.:1452849-80-7
Molecular Formula:C₁₈H₂₀N₂O₄S₃
Molecular Weight:424.566
Hs Code.:

Synonyms:(Z)-2-((methylsulfonamido)(benzylsulfanyl)methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid

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Chemical Property of (Z)-2-((methylsulfonamido)(benzylsulfanyl)methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid

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Technology Process of (Z)-2-((methylsulfonamido)(benzylsulfanyl)methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid

There total 4 articles about (Z)-2-((methylsulfonamido)(benzylsulfanyl)methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1452849-75-0
(Z)-tert-butyl 2-((methylsulfonamido)(benzylsulfanyl)-methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

: 1452849-80-7
(Z)-2-((methylsulfonamido)(benzylsulfanyl)methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jo4010876

Reference yield:

: 92932-02-0
2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid tert-butyl ester

: 1452849-80-7
(Z)-2-((methylsulfonamido)(benzylsulfanyl)methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: calcium carbonate / water; dichloromethane / 0.67 h / 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h

2.2: 1 h / 60 °C

3.1: water; sodium hydroxide / ethanol / 2 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With water; sodium hydride; trifluoroacetic acid; calcium carbonate; sodium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo4010876

Reference yield:

: 207743-78-0
tert-butyl 2-isothiocyanato-4,5,6,7-tetrahydrobenzo[b]-thiophene-3-carboxylate

: 1452849-80-7
(Z)-2-((methylsulfonamido)(benzylsulfanyl)methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h

1.2: 1 h / 60 °C

2.1: water; sodium hydroxide / ethanol / 2 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With water; sodium hydride; trifluoroacetic acid; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo4010876