(Z)-tert-butyl 2-((methylsulfonamido)(benzylsulfanyl)-methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Base Information

Chemical Name:(Z)-tert-butyl 2-((methylsulfonamido)(benzylsulfanyl)-methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate
CAS No.:1452849-75-0
Molecular Formula:C₂₂H₂₈N₂O₄S₃
Molecular Weight:480.673
Hs Code.:

Synonyms:(Z)-tert-butyl 2-((methylsulfonamido)(benzylsulfanyl)-methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

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Chemical Property of (Z)-tert-butyl 2-((methylsulfonamido)(benzylsulfanyl)-methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

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Technology Process of (Z)-tert-butyl 2-((methylsulfonamido)(benzylsulfanyl)-methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

There total 3 articles about (Z)-tert-butyl 2-((methylsulfonamido)(benzylsulfanyl)-methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1452776-84-9
tert-butyl 2-(3-(methylsulfonyl)thioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

: 100-39-0
benzyl bromide

: 1452849-75-0
(Z)-tert-butyl 2-((methylsulfonamido)(benzylsulfanyl)-methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Guidance literature:: With water; sodium hydroxide; In ethanol; at 20 ℃; for 2h;
DOI:10.1021/jo4010876

Reference yield:

: 92932-02-0
2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid tert-butyl ester

: 1452849-75-0
(Z)-tert-butyl 2-((methylsulfonamido)(benzylsulfanyl)-methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: calcium carbonate / water; dichloromethane / 0.67 h / 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h

2.2: 1 h / 60 °C

3.1: water; sodium hydroxide / ethanol / 2 h / 20 °C

With water; sodium hydride; calcium carbonate; sodium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo4010876

Reference yield:

: 207743-78-0
tert-butyl 2-isothiocyanato-4,5,6,7-tetrahydrobenzo[b]-thiophene-3-carboxylate

: 1452849-75-0
(Z)-tert-butyl 2-((methylsulfonamido)(benzylsulfanyl)-methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h

1.2: 1 h / 60 °C

2.1: water; sodium hydroxide / ethanol / 2 h / 20 °C

With water; sodium hydride; sodium hydroxide; In ethanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo4010876