diallyl 4-{[2'-(N,N-bis(2''-iodoethyl)amino)phenyl]carbamoyloxymethyl}phenylcarbamoyl-L-glutamate

Base Information

Chemical Name:diallyl 4-{[2'-(N,N-bis(2''-iodoethyl)amino)phenyl]carbamoyloxymethyl}phenylcarbamoyl-L-glutamate
CAS No.:528837-14-1
Molecular Formula:C₃₀H₃₆I₂N₄O₇
Molecular Weight:818.447
Hs Code.:

Synonyms:diallyl 4-{[2'-(N,N-bis(2''-iodoethyl)amino)phenyl]carbamoyloxymethyl}phenylcarbamoyl-L-glutamate

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Chemical Property of diallyl 4-{[2'-(N,N-bis(2''-iodoethyl)amino)phenyl]carbamoyloxymethyl}phenylcarbamoyl-L-glutamate

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Technology Process of diallyl 4-{[2'-(N,N-bis(2''-iodoethyl)amino)phenyl]carbamoyloxymethyl}phenylcarbamoyl-L-glutamate

There total 7 articles about diallyl 4-{[2'-(N,N-bis(2''-iodoethyl)amino)phenyl]carbamoyloxymethyl}phenylcarbamoyl-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.7%

: 528837-09-4
diallyl 4-{[2'-(N,N-bis(2''-mesyloxyethyl)amino)phenyl]carbamoyloxymethyl}phenylcarbamoyl-L-glutamate

: 528837-14-1
diallyl 4-{[2'-(N,N-bis(2''-iodoethyl)amino)phenyl]carbamoyloxymethyl}phenylcarbamoyl-L-glutamate

Guidance literature:: With sodium iodide; In acetone; Heating;
DOI:10.1021/jm020462i

Reference yield:

: 7334-82-9
N,N-bis(2-hydroxyethyl)-2-nitroaniline

: 528837-14-1
diallyl 4-{[2'-(N,N-bis(2''-iodoethyl)amino)phenyl]carbamoyloxymethyl}phenylcarbamoyl-L-glutamate

Guidance literature:: Multi-step reaction with 7 steps

1: 95.1 percent / imidazole / dimethylformamide / 20 °C

2: 99 percent / H₂ / Pd/C / tetrahydrofuran

3: Et₃N / CH₂Cl₂

4: 1.99 g / dibutyltin laurate / CH₂Cl₂ / 20 °C

5: 63.5 percent / triethylamine trihydrofluoride / tetrahydrofuran / 20 °C

6: 57 percent / 4-(N,N-dimethyl)aminopyridine; Et₃N / CH₂Cl₂ / 20 °C

7: 68.7 percent / NaI / acetone / Heating

With 1H-imidazole; dmap; dibutyltin(II) dilaurate; triethylamine trihydrofluoride; hydrogen; triethylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm020462i

Reference yield:

: 528836-34-2
2-nitro-N,N-bis[2'-(tert-butyldimethylsilyloxy)ethyl]aniline

: 528837-14-1
diallyl 4-{[2'-(N,N-bis(2''-iodoethyl)amino)phenyl]carbamoyloxymethyl}phenylcarbamoyl-L-glutamate

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / H₂ / Pd/C / tetrahydrofuran

2: Et₃N / CH₂Cl₂

3: 1.99 g / dibutyltin laurate / CH₂Cl₂ / 20 °C

4: 63.5 percent / triethylamine trihydrofluoride / tetrahydrofuran / 20 °C

5: 57 percent / 4-(N,N-dimethyl)aminopyridine; Et₃N / CH₂Cl₂ / 20 °C

6: 68.7 percent / NaI / acetone / Heating

With dmap; dibutyltin(II) dilaurate; triethylamine trihydrofluoride; hydrogen; triethylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1021/jm020462i