4-(2,5-dihydro-4-[4-(methylsulfonyl)phenyl]-2-oxofuran-3-yl)benzyl nitrate

Base Information

Chemical Name:4-(2,5-dihydro-4-[4-(methylsulfonyl)phenyl]-2-oxofuran-3-yl)benzyl nitrate
CAS No.:1242059-89-7
Molecular Formula:C₁₈H₁₅NO₇S
Molecular Weight:389.386
Hs Code.:

Synonyms:4-(2,5-dihydro-4-[4-(methylsulfonyl)phenyl]-2-oxofuran-3-yl)benzyl nitrate

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Chemical Property of 4-(2,5-dihydro-4-[4-(methylsulfonyl)phenyl]-2-oxofuran-3-yl)benzyl nitrate

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Technology Process of 4-(2,5-dihydro-4-[4-(methylsulfonyl)phenyl]-2-oxofuran-3-yl)benzyl nitrate

There total 2 articles about 4-(2,5-dihydro-4-[4-(methylsulfonyl)phenyl]-2-oxofuran-3-yl)benzyl nitrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1242059-88-6
3-[4-(hydroxymethyl)phenyl]-4-[4-(methylsulfonyl)phenyl]furan-2(5H)-one

: 1242059-89-7
4-(2,5-dihydro-4-[4-(methylsulfonyl)phenyl]-2-oxofuran-3-yl)benzyl nitrate

Guidance literature:: With N-Bromosuccinimide; silver nitrate; triphenylphosphine; In acetonitrile; at -15 - 20 ℃; for 25h; Inert atmosphere;
DOI:10.1002/cbdv.200900421

Reference yield:

: 50413-24-6
2-bromo-1-(4-methanesulfonylphenyl)ethanone

: 1242059-89-7
4-(2,5-dihydro-4-[4-(methylsulfonyl)phenyl]-2-oxofuran-3-yl)benzyl nitrate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / acetonitrile / 7 h / 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 1 h / 20 °C / Inert atmosphere

3: N-Bromosuccinimide; silver nitrate; triphenylphosphine / acetonitrile / 25 h / -15 - 20 °C / Inert atmosphere

With N-Bromosuccinimide; silver nitrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; In acetonitrile;
DOI:10.1002/cbdv.200900421