benzyl ((1-(benzyloxy)-3-iodo-5-methyl-1H-pyrazol-4-yl)methyl)carbamate

Base Information

Chemical Name:benzyl ((1-(benzyloxy)-3-iodo-5-methyl-1H-pyrazol-4-yl)methyl)carbamate
CAS No.:1421357-18-7
Molecular Formula:C₂₀H₂₀IN₃O₃
Molecular Weight:477.302
Hs Code.:

Synonyms:benzyl ((1-(benzyloxy)-3-iodo-5-methyl-1H-pyrazol-4-yl)methyl)carbamate

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Chemical Property of benzyl ((1-(benzyloxy)-3-iodo-5-methyl-1H-pyrazol-4-yl)methyl)carbamate

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Technology Process of benzyl ((1-(benzyloxy)-3-iodo-5-methyl-1H-pyrazol-4-yl)methyl)carbamate

There total 4 articles about benzyl ((1-(benzyloxy)-3-iodo-5-methyl-1H-pyrazol-4-yl)methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1421357-17-6
benzyl (1-(benzyloxy)-5-methyl-1H-pyrazol-4-yl)methylcarbamate

: 1421357-18-7
benzyl ((1-(benzyloxy)-3-iodo-5-methyl-1H-pyrazol-4-yl)methyl)carbamate

Guidance literature:: With Iodine monochloride; In water; acetic acid; at 85 ℃; for 23h;
DOI:10.1021/jm301473k

Reference yield:

: 229171-07-7
1-(benzyloxy)-4-iodo-1H-pyrazole

: 1421357-18-7
benzyl ((1-(benzyloxy)-3-iodo-5-methyl-1H-pyrazol-4-yl)methyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: isopropylmagnesium chloride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 18.5 h / 0 - 20 °C / Inert atmosphere

3: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 - -50 °C / Inert atmosphere

4: Iodine monochloride / water; acetic acid / 23 h / 85 °C

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; isopropylmagnesium chloride; Iodine monochloride; lithium diisopropyl amide; In tetrahydrofuran; methanol; water; acetic acid;
DOI:10.1021/jm301473k

Reference yield:

: 1421357-14-3
benzyl ((1-(benzyloxy)-1H-pyrazol-4-yl)methyl)carbamate

: 1421357-18-7
benzyl ((1-(benzyloxy)-3-iodo-5-methyl-1H-pyrazol-4-yl)methyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 - -50 °C / Inert atmosphere

2: Iodine monochloride / water; acetic acid / 23 h / 85 °C

With Iodine monochloride; lithium diisopropyl amide; In tetrahydrofuran; water; acetic acid;
DOI:10.1021/jm301473k