229171-07-7

Usage

Uses

1. Used in Pharmaceutical Synthesis:
1H-Pyrazole, 4-iodo-1-(phenylmethoxy)is used as an intermediate in the synthesis of amines and amino acids containing the pyrazole nucleus. Its unique structure allows for the development of novel bioactive molecules with potential applications in the pharmaceutical industry.
2. Used in the Synthesis of Aldose Reductase Inhibitors:
1H-Pyrazole, 4-iodo-1-(phenylmethoxy)is used as a bioisostere of the acetic acid moiety in a series of aldose reductase inhibitors. Aldose reductase inhibitors are important in the treatment of diabetic complications, and 1H-Pyrazole, 4-iodo-1-(phenylmethoxy)- contributes to the development of more effective inhibitors with improved pharmacological properties.

Upstream product

• 100-39-0 benzyl bromide 
• 217312-98-6 1-(benzyloxy)-5-(2-fluorophenyl)pyrazole 
• 100159-47-5 1-(benzyloxy)pyrazole 

Downstream Products

• 229171-24-8 1-benzyloxy-4-thiophen-2-yl-1H-pyrazole 
• 229171-17-9 4-(2-aminophenyl)-1-(benzyloxy)pyrazole 
• 100-51-6 benzyl alcohol 
• 323582-78-1 5-(2-aminophenyl)-1-benzyloxy-4-iodopyrazole 
• 350609-62-0 1-benzyloxy-4-(2-fluorophenyl)pyrazole 

Relevant academic research and scientific papers

N-hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands

A series of analogues based on N-hydroxypyrazole as a bioisostere for the distal carboxylate group of aspartate have been designed, synthesized, and pharmacologically characterized. Affinity studies on the major glutamate receptor subgroups show that thes

Novel 5-substituted 1-pyrazolol analogues of ibotenic acid: Synthesis and pharmacology at glutamate receptors

5-Substituted 1-pyrazolol analogues of ibotenic acid have been synthesized and pharmacologically characterized on ionotropic and metabotropic glutamate receptors (iGluRs and mGluRs). The syntheses involved introduction of bromide, alkyls, phenyl and aryla

Novel anionic annelation tactics for construction of fused heteroaromatic frameworks. 1. Synthesis of 4-substituted pyrazolo[4,3-c]quinolines, 9-substituted pyrazolo[3,4-c]quinolines, and 1,4-dihydrochromeno[4,3-c]pyrazoles

4-Substituted pyrazolo[4,3-c]quinolines 4a-i and 6a-b were prepared from pyrazole 3 whereas 9-substituted pyrazolo[3,4-c]quinolines 9a-d and 17 were prepared from pyrazole 13 utilizing anionic annelation techniques. 1,4-Dihydrochromeno[4,3- c]pyrazoles 7a-c were accessed from pyrazole 3, extending the method for the synthesis of 4a-i.